FOXO1 is a master regulator of CAR T memory programming

Poor CAR T persistence limits CAR T cell therapies for B cell malignancies and solid tumors(1,2). The expression of memory-associated genes such as TCF7 (protein name TCF1) is linked to response and long-term persistence in patients(3–7), thereby implicating memory programs in therapeutic efficacy....

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Detalles Bibliográficos
Autores principales: Doan, Alexander, Mueller, Katherine P., Chen, Andy, Rouin, Geoffrey T., Daniel, Bence, Lattin, John, Chen, Yingshi, Mozarsky, Brett, Markovska, Martina, Arias-Umana, Jose, Hapke, Robert, Jung, Inyoung, Xu, Peng, Klysz, Dorota, Bashti, Malek, Quinn, Patrick J, Sandor, Katalin, Zhang, Wenxi, Hall, Junior, Lareau, Caleb, Grupp, Stephan A., Fraietta, Joseph A., Sotillo, Elena, Satpathy, Ansuman T., Mackall, Crystal L., Weber, Evan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659532/
https://www.ncbi.nlm.nih.gov/pubmed/37986944
http://dx.doi.org/10.21203/rs.3.rs-2802998/v1

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