Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence

Mutations effects on p53 isoforms’ activities remain largely unknown, although they are mutated in 92% of TP53 mutant cancers. Therefore, exploring the effect of mutations on p53 isoforms activities is a critical, albeit unexplored area in the p53 field. In this article, we report for the first time...

Descripción completa

Detalles Bibliográficos
Autores principales: Harris, Curtis, Joruiz, Sebastien, Von Muhlinen, Natalia, Horikawa, Izumi, Gilbert, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659536/
https://www.ncbi.nlm.nih.gov/pubmed/37986881
http://dx.doi.org/10.21203/rs.3.rs-3370608/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659536/
https://www.ncbi.nlm.nih.gov/pubmed/37986881
http://dx.doi.org/10.21203/rs.3.rs-3370608/v1

Ejemplares similares