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Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study

To evaluate the causal relationship between genetically determined telomere length (TL) and atherosclerosis (AS). We performed a 2-sample Mendelian randomization (MR) study to assess the potential causal relationship between TL and AS (coronary AS, cerebral AS, peripheral atherosclerosis (PAD), and...

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Autores principales: Li, Wenwen, Liu, Cuncheng, Chen, Ying, Dong, Shoupeng, Zhang, Menghe, Sun, Jinglong, Zhao, Zhenfeng, Zuo, Yaoyao, Chen, Shouqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659599/
https://www.ncbi.nlm.nih.gov/pubmed/37986353
http://dx.doi.org/10.1097/MD.0000000000035875
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author Li, Wenwen
Liu, Cuncheng
Chen, Ying
Dong, Shoupeng
Zhang, Menghe
Sun, Jinglong
Zhao, Zhenfeng
Zuo, Yaoyao
Chen, Shouqiang
author_facet Li, Wenwen
Liu, Cuncheng
Chen, Ying
Dong, Shoupeng
Zhang, Menghe
Sun, Jinglong
Zhao, Zhenfeng
Zuo, Yaoyao
Chen, Shouqiang
author_sort Li, Wenwen
collection PubMed
description To evaluate the causal relationship between genetically determined telomere length (TL) and atherosclerosis (AS). We performed a 2-sample Mendelian randomization (MR) study to assess the potential causal relationship between TL and AS (coronary AS, cerebral AS, peripheral atherosclerosis (PAD), and AS, excluding cerebral, coronary, and PAD). The TL phenotype contained 472,174 participants, and the 4 subtypes of AS had 361,194, 218,792, 168,832, and 213,140 participants, all of European ancestries. The single nucleotide polymorphisms (SNPs) of TL strongly associated with the 4 atherosclerotic subtypes included in this study were 101, 92, 91, and 92, respectively. The odds ratios (ORs) and 95% confidence interval (CI) between TL and coronary AS calculated using inverse variance weighted (IVW) were 0.993 (0.988, 0.997), and the results were statistically significant (P < .05). The results between TL and cerebral AS, PAD, and AS (excluding cerebral, coronary, and PAD) were not statistically significant (P > .05). “Egger-intercept test” showed that there was no horizontal pleiotropy (P > .05); “leave-one-out analysis” sensitivity analysis showed that the results were stable and there were no instrumental variables with strong effects on the results; “MR- pleiotropy residual sum and outlier (PRESSO) test” showed 1 outlier for coronary AS and no outliers for the remaining subgroups. The results of the 2-sample MR analysis showed a causal association between TL and coronary AS but not with cerebral AS, PAD, and AS (excluding cerebral, coronary, and PAD). This may elucidate the observation that various vascular regions can be affected by AS but highlights the propensity of coronary arteries to be more susceptible to AS development.
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spelling pubmed-106595992023-11-17 Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study Li, Wenwen Liu, Cuncheng Chen, Ying Dong, Shoupeng Zhang, Menghe Sun, Jinglong Zhao, Zhenfeng Zuo, Yaoyao Chen, Shouqiang Medicine (Baltimore) 3400 To evaluate the causal relationship between genetically determined telomere length (TL) and atherosclerosis (AS). We performed a 2-sample Mendelian randomization (MR) study to assess the potential causal relationship between TL and AS (coronary AS, cerebral AS, peripheral atherosclerosis (PAD), and AS, excluding cerebral, coronary, and PAD). The TL phenotype contained 472,174 participants, and the 4 subtypes of AS had 361,194, 218,792, 168,832, and 213,140 participants, all of European ancestries. The single nucleotide polymorphisms (SNPs) of TL strongly associated with the 4 atherosclerotic subtypes included in this study were 101, 92, 91, and 92, respectively. The odds ratios (ORs) and 95% confidence interval (CI) between TL and coronary AS calculated using inverse variance weighted (IVW) were 0.993 (0.988, 0.997), and the results were statistically significant (P < .05). The results between TL and cerebral AS, PAD, and AS (excluding cerebral, coronary, and PAD) were not statistically significant (P > .05). “Egger-intercept test” showed that there was no horizontal pleiotropy (P > .05); “leave-one-out analysis” sensitivity analysis showed that the results were stable and there were no instrumental variables with strong effects on the results; “MR- pleiotropy residual sum and outlier (PRESSO) test” showed 1 outlier for coronary AS and no outliers for the remaining subgroups. The results of the 2-sample MR analysis showed a causal association between TL and coronary AS but not with cerebral AS, PAD, and AS (excluding cerebral, coronary, and PAD). This may elucidate the observation that various vascular regions can be affected by AS but highlights the propensity of coronary arteries to be more susceptible to AS development. Lippincott Williams & Wilkins 2023-11-17 /pmc/articles/PMC10659599/ /pubmed/37986353 http://dx.doi.org/10.1097/MD.0000000000035875 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 3400
Li, Wenwen
Liu, Cuncheng
Chen, Ying
Dong, Shoupeng
Zhang, Menghe
Sun, Jinglong
Zhao, Zhenfeng
Zuo, Yaoyao
Chen, Shouqiang
Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study
title Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study
title_full Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study
title_fullStr Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study
title_full_unstemmed Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study
title_short Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study
title_sort assessment of the relationship between telomere length and atherosclerosis: a mendelian randomization study
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659599/
https://www.ncbi.nlm.nih.gov/pubmed/37986353
http://dx.doi.org/10.1097/MD.0000000000035875
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