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Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study

INTRODUCTION: The healing of recurrent and refractory skin ulcers requires a long time, during which there is risk of infection, and hospital admission is occasionally required for surgical or daily conservative treatment. Therefore, the development of promising treatments that promote faster, uneve...

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Autores principales: Kawamoto, Shinichiro, Shinkawa, Eriko, Fujiwara, Susumu, Oda, Yoshiko, Jimbo, Haruki, Nakano, Eiji, Fukumoto, Takeshi, Ono, Ryusuke, Yasuda, Takahiro, Minami, Hironobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659605/
https://www.ncbi.nlm.nih.gov/pubmed/37986310
http://dx.doi.org/10.1097/MD.0000000000036134
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author Kawamoto, Shinichiro
Shinkawa, Eriko
Fujiwara, Susumu
Oda, Yoshiko
Jimbo, Haruki
Nakano, Eiji
Fukumoto, Takeshi
Ono, Ryusuke
Yasuda, Takahiro
Minami, Hironobu
author_facet Kawamoto, Shinichiro
Shinkawa, Eriko
Fujiwara, Susumu
Oda, Yoshiko
Jimbo, Haruki
Nakano, Eiji
Fukumoto, Takeshi
Ono, Ryusuke
Yasuda, Takahiro
Minami, Hironobu
author_sort Kawamoto, Shinichiro
collection PubMed
description INTRODUCTION: The healing of recurrent and refractory skin ulcers requires a long time, during which there is risk of infection, and hospital admission is occasionally required for surgical or daily conservative treatment. Therefore, the development of promising treatments that promote faster, uneventful healing is a must. Composed of cryoprecipitate and thrombin, fibrin glue has a history of surgical use for preventing bleeding and spinal fluid leakage. Moreover, in-house cryoprecipitates contain higher concentrations of coagulation factors and cytokines that may enhance wound healing than commercially available products. However, the efficacy of completely autologous fibrin glue (AFG) in tissue repair has not yet been fully demonstrated. PATIENT CONCERNS: This study aimed to evaluate the efficacy of AFG in the treatment of refractory skin ulcers in comparison with the conventional treatment. DIAGNOSIS: Two patients with skin ulcer on their lower extremities due to trauma or scleroderma who showed resistance to conventional treatment were included in the study. Both study participants were diagnosed with refractory skin ulcer and were ineligible for autologous skin transplantation. INTERVENTIONS: AFG was prepared following autologous blood donation using a Cryoseal(®) system. Subsequently, AFG was administered to 50% of the area of each ulcer and observed for 4 weeks in comparison with recombinant basic fibroblast growth factor with bucladesine sodium treatment that was administered to the rest of the ulcer. OUTCOMES: The skin ulcer after trauma in participant 1 showed better improvement in the AFG-treated area. Although AFG did not show superiority regarding the ulcer area of a patient with scleroderma, it guarded the continuous exudation from the edge of the swollen skin surrounding the ulcer. CONCLUSION: AFG showed effective and beneficial results for wound healing of refractory skin ulcer and prevented exudation without any severe adverse events.
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spelling pubmed-106596052023-11-17 Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study Kawamoto, Shinichiro Shinkawa, Eriko Fujiwara, Susumu Oda, Yoshiko Jimbo, Haruki Nakano, Eiji Fukumoto, Takeshi Ono, Ryusuke Yasuda, Takahiro Minami, Hironobu Medicine (Baltimore) 4000 INTRODUCTION: The healing of recurrent and refractory skin ulcers requires a long time, during which there is risk of infection, and hospital admission is occasionally required for surgical or daily conservative treatment. Therefore, the development of promising treatments that promote faster, uneventful healing is a must. Composed of cryoprecipitate and thrombin, fibrin glue has a history of surgical use for preventing bleeding and spinal fluid leakage. Moreover, in-house cryoprecipitates contain higher concentrations of coagulation factors and cytokines that may enhance wound healing than commercially available products. However, the efficacy of completely autologous fibrin glue (AFG) in tissue repair has not yet been fully demonstrated. PATIENT CONCERNS: This study aimed to evaluate the efficacy of AFG in the treatment of refractory skin ulcers in comparison with the conventional treatment. DIAGNOSIS: Two patients with skin ulcer on their lower extremities due to trauma or scleroderma who showed resistance to conventional treatment were included in the study. Both study participants were diagnosed with refractory skin ulcer and were ineligible for autologous skin transplantation. INTERVENTIONS: AFG was prepared following autologous blood donation using a Cryoseal(®) system. Subsequently, AFG was administered to 50% of the area of each ulcer and observed for 4 weeks in comparison with recombinant basic fibroblast growth factor with bucladesine sodium treatment that was administered to the rest of the ulcer. OUTCOMES: The skin ulcer after trauma in participant 1 showed better improvement in the AFG-treated area. Although AFG did not show superiority regarding the ulcer area of a patient with scleroderma, it guarded the continuous exudation from the edge of the swollen skin surrounding the ulcer. CONCLUSION: AFG showed effective and beneficial results for wound healing of refractory skin ulcer and prevented exudation without any severe adverse events. Lippincott Williams & Wilkins 2023-11-17 /pmc/articles/PMC10659605/ /pubmed/37986310 http://dx.doi.org/10.1097/MD.0000000000036134 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 4000
Kawamoto, Shinichiro
Shinkawa, Eriko
Fujiwara, Susumu
Oda, Yoshiko
Jimbo, Haruki
Nakano, Eiji
Fukumoto, Takeshi
Ono, Ryusuke
Yasuda, Takahiro
Minami, Hironobu
Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study
title Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study
title_full Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study
title_fullStr Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study
title_full_unstemmed Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study
title_short Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study
title_sort treatment of dermal ulcer with autologous fibrin glue: two case reports of an exploratory prospective pilot study
topic 4000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659605/
https://www.ncbi.nlm.nih.gov/pubmed/37986310
http://dx.doi.org/10.1097/MD.0000000000036134
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