Cargando…

Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review

RATIONALE: Non-Hodgkin lymphoma affecting the brain, eyes, and cerebrospinal fluid without systemic spread is known as primary central nervous system lymphoma (PCNSL). While intracerebroventricular PCNSL is commonly found in the lateral ventricles and the third and fourth ventricles, the occurrence...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Dawei, Yan, Xu, Lu, Liuzhe, Xue, Kun, Dong, Xuechao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659664/
https://www.ncbi.nlm.nih.gov/pubmed/37986283
http://dx.doi.org/10.1097/MD.0000000000035954
_version_ 1785148360451162112
author Chen, Dawei
Yan, Xu
Lu, Liuzhe
Xue, Kun
Dong, Xuechao
author_facet Chen, Dawei
Yan, Xu
Lu, Liuzhe
Xue, Kun
Dong, Xuechao
author_sort Chen, Dawei
collection PubMed
description RATIONALE: Non-Hodgkin lymphoma affecting the brain, eyes, and cerebrospinal fluid without systemic spread is known as primary central nervous system lymphoma (PCNSL). While intracerebroventricular PCNSL is commonly found in the lateral ventricles and the third and fourth ventricles, the occurrence of PCNSL originating from the septum pellucidum is extremely rare. PATIENT CONCERNS: Two patients presented with recent memory loss and high cranial pressure. DIAGNOSES: Magnetic resonance imaging revealed a clear enhancing lesion in the septum pellucidum region. Pathological examination confirmed that both cases were primary large B-cell lymphoma GCB (germinal center B-cell-like) subtypes located in an “immune-privileged” area. INTERVENTIONS: Both patients underwent total tumor resection, and the procedures were successfully completed without surgical complications. OUTCOMES: Over a 1-year period, treatment included four cycles of high-dose methotrexate combined with temozolomide. During the follow-up period (19–23 months), no recurrence of the lymphoma was observed. LESSONS: In cases of PCNSL in the septum pellucidum, it is crucial to consider it as a potential differential diagnosis for intraventricular tumors. Surgical interventions should focus on maximizing tumor resection while ensuring the protection of critical structures like the fornix and peripheral neural components. The role of surgery compared to biopsy, as well as the long-term complications, necessitates extended follow-up. Additionally, an individualized treatment approach, considering factors such as age, Karnofsky performance score, and organ function assessment, can lead to positive outcomes.
format Online
Article
Text
id pubmed-10659664
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-106596642023-11-17 Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review Chen, Dawei Yan, Xu Lu, Liuzhe Xue, Kun Dong, Xuechao Medicine (Baltimore) 5700 RATIONALE: Non-Hodgkin lymphoma affecting the brain, eyes, and cerebrospinal fluid without systemic spread is known as primary central nervous system lymphoma (PCNSL). While intracerebroventricular PCNSL is commonly found in the lateral ventricles and the third and fourth ventricles, the occurrence of PCNSL originating from the septum pellucidum is extremely rare. PATIENT CONCERNS: Two patients presented with recent memory loss and high cranial pressure. DIAGNOSES: Magnetic resonance imaging revealed a clear enhancing lesion in the septum pellucidum region. Pathological examination confirmed that both cases were primary large B-cell lymphoma GCB (germinal center B-cell-like) subtypes located in an “immune-privileged” area. INTERVENTIONS: Both patients underwent total tumor resection, and the procedures were successfully completed without surgical complications. OUTCOMES: Over a 1-year period, treatment included four cycles of high-dose methotrexate combined with temozolomide. During the follow-up period (19–23 months), no recurrence of the lymphoma was observed. LESSONS: In cases of PCNSL in the septum pellucidum, it is crucial to consider it as a potential differential diagnosis for intraventricular tumors. Surgical interventions should focus on maximizing tumor resection while ensuring the protection of critical structures like the fornix and peripheral neural components. The role of surgery compared to biopsy, as well as the long-term complications, necessitates extended follow-up. Additionally, an individualized treatment approach, considering factors such as age, Karnofsky performance score, and organ function assessment, can lead to positive outcomes. Lippincott Williams & Wilkins 2023-11-17 /pmc/articles/PMC10659664/ /pubmed/37986283 http://dx.doi.org/10.1097/MD.0000000000035954 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Chen, Dawei
Yan, Xu
Lu, Liuzhe
Xue, Kun
Dong, Xuechao
Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review
title Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review
title_full Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review
title_fullStr Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review
title_full_unstemmed Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review
title_short Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review
title_sort lymphoma of the central nervous system originating from the septum pellucidum region: two case reports with literature review
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659664/
https://www.ncbi.nlm.nih.gov/pubmed/37986283
http://dx.doi.org/10.1097/MD.0000000000035954
work_keys_str_mv AT chendawei lymphomaofthecentralnervoussystemoriginatingfromtheseptumpellucidumregiontwocasereportswithliteraturereview
AT yanxu lymphomaofthecentralnervoussystemoriginatingfromtheseptumpellucidumregiontwocasereportswithliteraturereview
AT luliuzhe lymphomaofthecentralnervoussystemoriginatingfromtheseptumpellucidumregiontwocasereportswithliteraturereview
AT xuekun lymphomaofthecentralnervoussystemoriginatingfromtheseptumpellucidumregiontwocasereportswithliteraturereview
AT dongxuechao lymphomaofthecentralnervoussystemoriginatingfromtheseptumpellucidumregiontwocasereportswithliteraturereview