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Engineering the next generation of theranostic biomaterials with synthetic biology

Biomaterials have evolved from inert materials to responsive entities, playing a crucial role in disease diagnosis, treatment, and modeling. However, their advancement is hindered by limitations in chemical and mechanical approaches. Synthetic biology enabling the genetically reprograming of biologi...

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Detalles Bibliográficos
Autores principales: Wang, Xiang, Liang, Qianyi, Luo, Yixuan, Ye, Jianwen, Yu, Yin, Chen, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660023/
https://www.ncbi.nlm.nih.gov/pubmed/38026437
http://dx.doi.org/10.1016/j.bioactmat.2023.10.018
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author Wang, Xiang
Liang, Qianyi
Luo, Yixuan
Ye, Jianwen
Yu, Yin
Chen, Fei
author_facet Wang, Xiang
Liang, Qianyi
Luo, Yixuan
Ye, Jianwen
Yu, Yin
Chen, Fei
author_sort Wang, Xiang
collection PubMed
description Biomaterials have evolved from inert materials to responsive entities, playing a crucial role in disease diagnosis, treatment, and modeling. However, their advancement is hindered by limitations in chemical and mechanical approaches. Synthetic biology enabling the genetically reprograming of biological systems offers a new paradigm. It has achieved remarkable progresses in cell reprogramming, engineering designer cells for diverse applications. Synthetic biology also encompasses cell-free systems and rational design of biological molecules. This review focuses on the application of synthetic biology in theranostics, which boost rapid development of advanced biomaterials. We introduce key fundamental concepts of synthetic biology and highlight frontier applications thereof, aiming to explore the intersection of synthetic biology and biomaterials. This integration holds tremendous promise for advancing biomaterial engineering with programable complex functions.
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spelling pubmed-106600232023-11-03 Engineering the next generation of theranostic biomaterials with synthetic biology Wang, Xiang Liang, Qianyi Luo, Yixuan Ye, Jianwen Yu, Yin Chen, Fei Bioact Mater Review Article Biomaterials have evolved from inert materials to responsive entities, playing a crucial role in disease diagnosis, treatment, and modeling. However, their advancement is hindered by limitations in chemical and mechanical approaches. Synthetic biology enabling the genetically reprograming of biological systems offers a new paradigm. It has achieved remarkable progresses in cell reprogramming, engineering designer cells for diverse applications. Synthetic biology also encompasses cell-free systems and rational design of biological molecules. This review focuses on the application of synthetic biology in theranostics, which boost rapid development of advanced biomaterials. We introduce key fundamental concepts of synthetic biology and highlight frontier applications thereof, aiming to explore the intersection of synthetic biology and biomaterials. This integration holds tremendous promise for advancing biomaterial engineering with programable complex functions. KeAi Publishing 2023-11-03 /pmc/articles/PMC10660023/ /pubmed/38026437 http://dx.doi.org/10.1016/j.bioactmat.2023.10.018 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Wang, Xiang
Liang, Qianyi
Luo, Yixuan
Ye, Jianwen
Yu, Yin
Chen, Fei
Engineering the next generation of theranostic biomaterials with synthetic biology
title Engineering the next generation of theranostic biomaterials with synthetic biology
title_full Engineering the next generation of theranostic biomaterials with synthetic biology
title_fullStr Engineering the next generation of theranostic biomaterials with synthetic biology
title_full_unstemmed Engineering the next generation of theranostic biomaterials with synthetic biology
title_short Engineering the next generation of theranostic biomaterials with synthetic biology
title_sort engineering the next generation of theranostic biomaterials with synthetic biology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660023/
https://www.ncbi.nlm.nih.gov/pubmed/38026437
http://dx.doi.org/10.1016/j.bioactmat.2023.10.018
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