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TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells

The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation o...

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Autores principales: Ríos-López, Diana G., Tecalco-Cruz, Angeles C., Martínez-Pastor, David, Sosa-Garrocho, Marcela, Tapia-Urzúa, Gustavo, Aranda-López, Yuli, Ortega-Domínguez, Bibiana, Recillas-Targa, Félix, Vázquez-Victorio, Genaro, Macías-Silva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660035/
https://www.ncbi.nlm.nih.gov/pubmed/38027697
http://dx.doi.org/10.1016/j.heliyon.2023.e21519
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author Ríos-López, Diana G.
Tecalco-Cruz, Angeles C.
Martínez-Pastor, David
Sosa-Garrocho, Marcela
Tapia-Urzúa, Gustavo
Aranda-López, Yuli
Ortega-Domínguez, Bibiana
Recillas-Targa, Félix
Vázquez-Victorio, Genaro
Macías-Silva, Marina
author_facet Ríos-López, Diana G.
Tecalco-Cruz, Angeles C.
Martínez-Pastor, David
Sosa-Garrocho, Marcela
Tapia-Urzúa, Gustavo
Aranda-López, Yuli
Ortega-Domínguez, Bibiana
Recillas-Targa, Félix
Vázquez-Victorio, Genaro
Macías-Silva, Marina
author_sort Ríos-López, Diana G.
collection PubMed
description The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation of TAZ expression has been associated with liver cancer progression. Recent evidence shows crosstalk of TGF-β and Hippo pathways, since TGF-β modulates TAZ expression through different mechanisms in a cellular context-dependent manner but supposedly independent of SMADs. Here, we evaluate the molecular interplay between TGF-β pathway and TAZ expression and observe that TGF-β induces TAZ expression through SMAD canonical pathway in liver cancer HepG2 cells. Therefore, TAZ cofactor is a primary target of TGF-β/SMAD-signaling, one of the pathways altered in liver cancer.
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spelling pubmed-106600352023-10-31 TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells Ríos-López, Diana G. Tecalco-Cruz, Angeles C. Martínez-Pastor, David Sosa-Garrocho, Marcela Tapia-Urzúa, Gustavo Aranda-López, Yuli Ortega-Domínguez, Bibiana Recillas-Targa, Félix Vázquez-Victorio, Genaro Macías-Silva, Marina Heliyon Research Article The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation of TAZ expression has been associated with liver cancer progression. Recent evidence shows crosstalk of TGF-β and Hippo pathways, since TGF-β modulates TAZ expression through different mechanisms in a cellular context-dependent manner but supposedly independent of SMADs. Here, we evaluate the molecular interplay between TGF-β pathway and TAZ expression and observe that TGF-β induces TAZ expression through SMAD canonical pathway in liver cancer HepG2 cells. Therefore, TAZ cofactor is a primary target of TGF-β/SMAD-signaling, one of the pathways altered in liver cancer. Elsevier 2023-10-31 /pmc/articles/PMC10660035/ /pubmed/38027697 http://dx.doi.org/10.1016/j.heliyon.2023.e21519 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Ríos-López, Diana G.
Tecalco-Cruz, Angeles C.
Martínez-Pastor, David
Sosa-Garrocho, Marcela
Tapia-Urzúa, Gustavo
Aranda-López, Yuli
Ortega-Domínguez, Bibiana
Recillas-Targa, Félix
Vázquez-Victorio, Genaro
Macías-Silva, Marina
TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
title TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
title_full TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
title_fullStr TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
title_full_unstemmed TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
title_short TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
title_sort tgf-β/smad canonical pathway induces the expression of transcriptional cofactor taz in liver cancer cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660035/
https://www.ncbi.nlm.nih.gov/pubmed/38027697
http://dx.doi.org/10.1016/j.heliyon.2023.e21519
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