Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma

Lymphoma is one of the most common cancers in adolescents and young adults, but historically, this population has had lower clinical trial enrollment and improvements in overall survival as compared to other age populations. There are multiple challenges that are unique to this population that have...

Descripción completa

Detalles Bibliográficos
Autores principales: Toner, Keri, Allen, Carl E., Jain, Shweta, Kahl, Brad, Leonard, John, Wasserstrom, Heather, Friedberg, Jonathan W., Seibel, Nita L., Kelly, Kara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Adolescent and Young Adults (Aya) Lymphomas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660108/
https://www.ncbi.nlm.nih.gov/pubmed/38024612
http://dx.doi.org/10.1002/jha2.787
_version_ 1785137692371058688
author Toner, Keri
Allen, Carl E.
Jain, Shweta
Kahl, Brad
Leonard, John
Wasserstrom, Heather
Friedberg, Jonathan W.
Seibel, Nita L.
Kelly, Kara
author_facet Toner, Keri
Allen, Carl E.
Jain, Shweta
Kahl, Brad
Leonard, John
Wasserstrom, Heather
Friedberg, Jonathan W.
Seibel, Nita L.
Kelly, Kara
author_sort Toner, Keri
collection PubMed
description Lymphoma is one of the most common cancers in adolescents and young adults, but historically, this population has had lower clinical trial enrollment and improvements in overall survival as compared to other age populations. There are multiple challenges that are unique to this population that have affected drug development and clinical trial enrollment. Our panel of experts have identified barriers, and in this review, we discuss current methods to address these barriers as well as potential solutions moving forward.
format Online
Article
Text
id pubmed-10660108
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-106601082023-09-07 Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma Toner, Keri Allen, Carl E. Jain, Shweta Kahl, Brad Leonard, John Wasserstrom, Heather Friedberg, Jonathan W. Seibel, Nita L. Kelly, Kara EJHaem Adolescent and Young Adults (Aya) Lymphomas Lymphoma is one of the most common cancers in adolescents and young adults, but historically, this population has had lower clinical trial enrollment and improvements in overall survival as compared to other age populations. There are multiple challenges that are unique to this population that have affected drug development and clinical trial enrollment. Our panel of experts have identified barriers, and in this review, we discuss current methods to address these barriers as well as potential solutions moving forward. John Wiley and Sons Inc. 2023-09-07 /pmc/articles/PMC10660108/ /pubmed/38024612 http://dx.doi.org/10.1002/jha2.787 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Adolescent and Young Adults (Aya) Lymphomas
Toner, Keri
Allen, Carl E.
Jain, Shweta
Kahl, Brad
Leonard, John
Wasserstrom, Heather
Friedberg, Jonathan W.
Seibel, Nita L.
Kelly, Kara
Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
title Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
title_full Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
title_fullStr Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
title_full_unstemmed Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
title_short Overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
title_sort overcoming barriers to drug development and enrollment in clinical trials for adolescents and young adults with lymphoma
topic Adolescent and Young Adults (Aya) Lymphomas
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660108/
https://www.ncbi.nlm.nih.gov/pubmed/38024612
http://dx.doi.org/10.1002/jha2.787
work_keys_str_mv AT tonerkeri overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT allencarle overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT jainshweta overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT kahlbrad overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT leonardjohn overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT wasserstromheather overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT friedbergjonathanw overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT seibelnital overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma
AT kellykara overcomingbarrierstodrugdevelopmentandenrollmentinclinicaltrialsforadolescentsandyoungadultswithlymphoma

Ejemplares similares