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Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions

PURPOSE: Diffusion kurtosis imaging (DKI) is an MRI method related to diffusion imaging (DWI) that is distinguished by a non-Gaussian calculation of water particles movements in tissues. The aim of the study was to assess DKI advantage over DWI in differentiating benign and malignant liver lesions....

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Autores principales: Podgórska, Joanna, Pasicz, Katarzyna, Skrzyński, Witold, Gołębiewski, Bogumił, Kuś, Piotr, Jasieniak, Jakub, Rogowska, Agnieszka, Kukołowicz, Paweł, Cieszanowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660143/
https://www.ncbi.nlm.nih.gov/pubmed/38020499
http://dx.doi.org/10.5114/pjr.2023.131911
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author Podgórska, Joanna
Pasicz, Katarzyna
Skrzyński, Witold
Gołębiewski, Bogumił
Kuś, Piotr
Jasieniak, Jakub
Rogowska, Agnieszka
Kukołowicz, Paweł
Cieszanowski, Andrzej
author_facet Podgórska, Joanna
Pasicz, Katarzyna
Skrzyński, Witold
Gołębiewski, Bogumił
Kuś, Piotr
Jasieniak, Jakub
Rogowska, Agnieszka
Kukołowicz, Paweł
Cieszanowski, Andrzej
author_sort Podgórska, Joanna
collection PubMed
description PURPOSE: Diffusion kurtosis imaging (DKI) is an MRI method related to diffusion imaging (DWI) that is distinguished by a non-Gaussian calculation of water particles movements in tissues. The aim of the study was to assess DKI advantage over DWI in differentiating benign and malignant liver lesions. MATERIAL AND METHODS: Analysis included prospectively acquired group of 83 patients referred consecutively for 3T-MRI liver tumor examination, with 95 liver lesions (31 benign, 59 malignant). MRI assessments were performed with standard protocol and DKI sequence with seven b-values (0-2,000 s/mm(2)). Quantitative data were acquired by placing ROIs in liver tumors on all b-value images, ROI data extracted, and calculation of DWI and DKI parameters. ADC was calculated for all b-values (ADC(0-2000)) and for three values of b = 0, 500, and 750 (s/mm(2)) (ADC(0-500-750)). DKI and ADC parameters for benign and malignant lesions were compared, and ROC curves were plotted. RESULTS: Significant differences were obtained for all DKI and ADC parameters. ROC analysis showed AUC of D(K), K, ADC(0-2000), and ADC(0-500-750) was 0.74, 0.77, 0.77, and 0.75, respectively. The highest sensitivity (of 0.91) was obtained for ADC(0-2000). The highest specificity (0.65) and accuracy (0.80) was obtained for K. CONCLUSION: DKI technique yields statistically comparable results with DWI technique.
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spelling pubmed-106601432023-01-01 Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions Podgórska, Joanna Pasicz, Katarzyna Skrzyński, Witold Gołębiewski, Bogumił Kuś, Piotr Jasieniak, Jakub Rogowska, Agnieszka Kukołowicz, Paweł Cieszanowski, Andrzej Pol J Radiol Original Paper PURPOSE: Diffusion kurtosis imaging (DKI) is an MRI method related to diffusion imaging (DWI) that is distinguished by a non-Gaussian calculation of water particles movements in tissues. The aim of the study was to assess DKI advantage over DWI in differentiating benign and malignant liver lesions. MATERIAL AND METHODS: Analysis included prospectively acquired group of 83 patients referred consecutively for 3T-MRI liver tumor examination, with 95 liver lesions (31 benign, 59 malignant). MRI assessments were performed with standard protocol and DKI sequence with seven b-values (0-2,000 s/mm(2)). Quantitative data were acquired by placing ROIs in liver tumors on all b-value images, ROI data extracted, and calculation of DWI and DKI parameters. ADC was calculated for all b-values (ADC(0-2000)) and for three values of b = 0, 500, and 750 (s/mm(2)) (ADC(0-500-750)). DKI and ADC parameters for benign and malignant lesions were compared, and ROC curves were plotted. RESULTS: Significant differences were obtained for all DKI and ADC parameters. ROC analysis showed AUC of D(K), K, ADC(0-2000), and ADC(0-500-750) was 0.74, 0.77, 0.77, and 0.75, respectively. The highest sensitivity (of 0.91) was obtained for ADC(0-2000). The highest specificity (0.65) and accuracy (0.80) was obtained for K. CONCLUSION: DKI technique yields statistically comparable results with DWI technique. Termedia Publishing House 2023-10-04 /pmc/articles/PMC10660143/ /pubmed/38020499 http://dx.doi.org/10.5114/pjr.2023.131911 Text en © Pol J Radiol 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Paper
Podgórska, Joanna
Pasicz, Katarzyna
Skrzyński, Witold
Gołębiewski, Bogumił
Kuś, Piotr
Jasieniak, Jakub
Rogowska, Agnieszka
Kukołowicz, Paweł
Cieszanowski, Andrzej
Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
title Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
title_full Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
title_fullStr Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
title_full_unstemmed Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
title_short Application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
title_sort application of diffusion kurtosis imaging in differential diagnosis of focal liver lesions
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660143/
https://www.ncbi.nlm.nih.gov/pubmed/38020499
http://dx.doi.org/10.5114/pjr.2023.131911
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