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Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history

We report about a man in his mid-50s who was prescribed pregabalin (150 mg/day) for neuropathic pain due to a herniated intervertebral disc. Four weeks later, he presented to the emergency room with symptoms consistent with delirium. After ruling out acute intoxication with a substance and neurologi...

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Autores principales: Awasthi, Harshal, Vohra, Abhimanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660150/
https://www.ncbi.nlm.nih.gov/pubmed/37977830
http://dx.doi.org/10.1136/bcr-2023-258104
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author Awasthi, Harshal
Vohra, Abhimanyu
author_facet Awasthi, Harshal
Vohra, Abhimanyu
author_sort Awasthi, Harshal
collection PubMed
description We report about a man in his mid-50s who was prescribed pregabalin (150 mg/day) for neuropathic pain due to a herniated intervertebral disc. Four weeks later, he presented to the emergency room with symptoms consistent with delirium. After ruling out acute intoxication with a substance and neurological causes, collateral information from the family and review of his medical chart indicated potential discontinuation syndrome owing to pregabalin. Following the successful treatment and resolution of delirium, the patient revealed he had been consistently consuming pregabalin doses upwards of 2 g/day over the past 2 weeks, leading to the premature exhaustion of his prescription and an abrupt cessation. The case findings underscore the necessity for physicians to recognise the potential for pregabalin misuse and the associated withdrawal risks, including delirium.
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spelling pubmed-106601502023-11-17 Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history Awasthi, Harshal Vohra, Abhimanyu BMJ Case Rep Psychiatry We report about a man in his mid-50s who was prescribed pregabalin (150 mg/day) for neuropathic pain due to a herniated intervertebral disc. Four weeks later, he presented to the emergency room with symptoms consistent with delirium. After ruling out acute intoxication with a substance and neurological causes, collateral information from the family and review of his medical chart indicated potential discontinuation syndrome owing to pregabalin. Following the successful treatment and resolution of delirium, the patient revealed he had been consistently consuming pregabalin doses upwards of 2 g/day over the past 2 weeks, leading to the premature exhaustion of his prescription and an abrupt cessation. The case findings underscore the necessity for physicians to recognise the potential for pregabalin misuse and the associated withdrawal risks, including delirium. BMJ Publishing Group 2023-11-17 /pmc/articles/PMC10660150/ /pubmed/37977830 http://dx.doi.org/10.1136/bcr-2023-258104 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Psychiatry
Awasthi, Harshal
Vohra, Abhimanyu
Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
title Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
title_full Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
title_fullStr Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
title_full_unstemmed Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
title_short Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
title_sort delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660150/
https://www.ncbi.nlm.nih.gov/pubmed/37977830
http://dx.doi.org/10.1136/bcr-2023-258104
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