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Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history
We report about a man in his mid-50s who was prescribed pregabalin (150 mg/day) for neuropathic pain due to a herniated intervertebral disc. Four weeks later, he presented to the emergency room with symptoms consistent with delirium. After ruling out acute intoxication with a substance and neurologi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660150/ https://www.ncbi.nlm.nih.gov/pubmed/37977830 http://dx.doi.org/10.1136/bcr-2023-258104 |
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author | Awasthi, Harshal Vohra, Abhimanyu |
author_facet | Awasthi, Harshal Vohra, Abhimanyu |
author_sort | Awasthi, Harshal |
collection | PubMed |
description | We report about a man in his mid-50s who was prescribed pregabalin (150 mg/day) for neuropathic pain due to a herniated intervertebral disc. Four weeks later, he presented to the emergency room with symptoms consistent with delirium. After ruling out acute intoxication with a substance and neurological causes, collateral information from the family and review of his medical chart indicated potential discontinuation syndrome owing to pregabalin. Following the successful treatment and resolution of delirium, the patient revealed he had been consistently consuming pregabalin doses upwards of 2 g/day over the past 2 weeks, leading to the premature exhaustion of his prescription and an abrupt cessation. The case findings underscore the necessity for physicians to recognise the potential for pregabalin misuse and the associated withdrawal risks, including delirium. |
format | Online Article Text |
id | pubmed-10660150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-106601502023-11-17 Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history Awasthi, Harshal Vohra, Abhimanyu BMJ Case Rep Psychiatry We report about a man in his mid-50s who was prescribed pregabalin (150 mg/day) for neuropathic pain due to a herniated intervertebral disc. Four weeks later, he presented to the emergency room with symptoms consistent with delirium. After ruling out acute intoxication with a substance and neurological causes, collateral information from the family and review of his medical chart indicated potential discontinuation syndrome owing to pregabalin. Following the successful treatment and resolution of delirium, the patient revealed he had been consistently consuming pregabalin doses upwards of 2 g/day over the past 2 weeks, leading to the premature exhaustion of his prescription and an abrupt cessation. The case findings underscore the necessity for physicians to recognise the potential for pregabalin misuse and the associated withdrawal risks, including delirium. BMJ Publishing Group 2023-11-17 /pmc/articles/PMC10660150/ /pubmed/37977830 http://dx.doi.org/10.1136/bcr-2023-258104 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Psychiatry Awasthi, Harshal Vohra, Abhimanyu Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history |
title | Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history |
title_full | Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history |
title_fullStr | Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history |
title_full_unstemmed | Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history |
title_short | Delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history |
title_sort | delirium following pregabalin discontinuation in an individual with no psychiatric or substance use history |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660150/ https://www.ncbi.nlm.nih.gov/pubmed/37977830 http://dx.doi.org/10.1136/bcr-2023-258104 |
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