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Sodium valproate: cacosmia and dysgeusia as uncommon side effects
Smell and taste disturbances are potential adverse reactions of many drugs used in Psychiatry, such as antidepressants, anti-Parkinson agents, lithium, minor and major tranquilizers. To our knowledge, only one clinical case regarding valproate and cacosmia has been reported so far. However, several...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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UMF “Gr. T. Popa” Iasi Publishing House
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660243/ https://www.ncbi.nlm.nih.gov/pubmed/38026105 http://dx.doi.org/10.22551/2023.41.1004.10265 |
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author | Montalbano, Clara Raia, Accursio Caruso, Valerio Migli, Lavinia |
author_facet | Montalbano, Clara Raia, Accursio Caruso, Valerio Migli, Lavinia |
author_sort | Montalbano, Clara |
collection | PubMed |
description | Smell and taste disturbances are potential adverse reactions of many drugs used in Psychiatry, such as antidepressants, anti-Parkinson agents, lithium, minor and major tranquilizers. To our knowledge, only one clinical case regarding valproate and cacosmia has been reported so far. However, several anticonvulsants are reported to cause taste and smell disturbances, although the underlying etiology is currently unclear. Our patient developed cacosmia and dysgeusia when taking valproic acid, both effects quickly disappeared upon drug discontinuation. In this article we not only report this uncommon side effect, but we discuss the plausible mechanisms behind such an adverse reaction. Our case is to date the second similar case in the literature. The aim of the present article is to make clinicians informed about this very uncommon and unpleasant side effect. |
format | Online Article Text |
id | pubmed-10660243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | UMF “Gr. T. Popa” Iasi Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-106602432023-11-21 Sodium valproate: cacosmia and dysgeusia as uncommon side effects Montalbano, Clara Raia, Accursio Caruso, Valerio Migli, Lavinia Arch Clin Cases Case Report Smell and taste disturbances are potential adverse reactions of many drugs used in Psychiatry, such as antidepressants, anti-Parkinson agents, lithium, minor and major tranquilizers. To our knowledge, only one clinical case regarding valproate and cacosmia has been reported so far. However, several anticonvulsants are reported to cause taste and smell disturbances, although the underlying etiology is currently unclear. Our patient developed cacosmia and dysgeusia when taking valproic acid, both effects quickly disappeared upon drug discontinuation. In this article we not only report this uncommon side effect, but we discuss the plausible mechanisms behind such an adverse reaction. Our case is to date the second similar case in the literature. The aim of the present article is to make clinicians informed about this very uncommon and unpleasant side effect. UMF “Gr. T. Popa” Iasi Publishing House 2023-11-21 /pmc/articles/PMC10660243/ /pubmed/38026105 http://dx.doi.org/10.22551/2023.41.1004.10265 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Montalbano, Clara Raia, Accursio Caruso, Valerio Migli, Lavinia Sodium valproate: cacosmia and dysgeusia as uncommon side effects |
title | Sodium valproate: cacosmia and dysgeusia as uncommon side effects |
title_full | Sodium valproate: cacosmia and dysgeusia as uncommon side effects |
title_fullStr | Sodium valproate: cacosmia and dysgeusia as uncommon side effects |
title_full_unstemmed | Sodium valproate: cacosmia and dysgeusia as uncommon side effects |
title_short | Sodium valproate: cacosmia and dysgeusia as uncommon side effects |
title_sort | sodium valproate: cacosmia and dysgeusia as uncommon side effects |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660243/ https://www.ncbi.nlm.nih.gov/pubmed/38026105 http://dx.doi.org/10.22551/2023.41.1004.10265 |
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