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Sodium valproate: cacosmia and dysgeusia as uncommon side effects

Smell and taste disturbances are potential adverse reactions of many drugs used in Psychiatry, such as antidepressants, anti-Parkinson agents, lithium, minor and major tranquilizers. To our knowledge, only one clinical case regarding valproate and cacosmia has been reported so far. However, several...

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Detalles Bibliográficos
Autores principales: Montalbano, Clara, Raia, Accursio, Caruso, Valerio, Migli, Lavinia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: UMF “Gr. T. Popa” Iasi Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660243/
https://www.ncbi.nlm.nih.gov/pubmed/38026105
http://dx.doi.org/10.22551/2023.41.1004.10265
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author Montalbano, Clara
Raia, Accursio
Caruso, Valerio
Migli, Lavinia
author_facet Montalbano, Clara
Raia, Accursio
Caruso, Valerio
Migli, Lavinia
author_sort Montalbano, Clara
collection PubMed
description Smell and taste disturbances are potential adverse reactions of many drugs used in Psychiatry, such as antidepressants, anti-Parkinson agents, lithium, minor and major tranquilizers. To our knowledge, only one clinical case regarding valproate and cacosmia has been reported so far. However, several anticonvulsants are reported to cause taste and smell disturbances, although the underlying etiology is currently unclear. Our patient developed cacosmia and dysgeusia when taking valproic acid, both effects quickly disappeared upon drug discontinuation. In this article we not only report this uncommon side effect, but we discuss the plausible mechanisms behind such an adverse reaction. Our case is to date the second similar case in the literature. The aim of the present article is to make clinicians informed about this very uncommon and unpleasant side effect.
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spelling pubmed-106602432023-11-21 Sodium valproate: cacosmia and dysgeusia as uncommon side effects Montalbano, Clara Raia, Accursio Caruso, Valerio Migli, Lavinia Arch Clin Cases Case Report Smell and taste disturbances are potential adverse reactions of many drugs used in Psychiatry, such as antidepressants, anti-Parkinson agents, lithium, minor and major tranquilizers. To our knowledge, only one clinical case regarding valproate and cacosmia has been reported so far. However, several anticonvulsants are reported to cause taste and smell disturbances, although the underlying etiology is currently unclear. Our patient developed cacosmia and dysgeusia when taking valproic acid, both effects quickly disappeared upon drug discontinuation. In this article we not only report this uncommon side effect, but we discuss the plausible mechanisms behind such an adverse reaction. Our case is to date the second similar case in the literature. The aim of the present article is to make clinicians informed about this very uncommon and unpleasant side effect. UMF “Gr. T. Popa” Iasi Publishing House 2023-11-21 /pmc/articles/PMC10660243/ /pubmed/38026105 http://dx.doi.org/10.22551/2023.41.1004.10265 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Montalbano, Clara
Raia, Accursio
Caruso, Valerio
Migli, Lavinia
Sodium valproate: cacosmia and dysgeusia as uncommon side effects
title Sodium valproate: cacosmia and dysgeusia as uncommon side effects
title_full Sodium valproate: cacosmia and dysgeusia as uncommon side effects
title_fullStr Sodium valproate: cacosmia and dysgeusia as uncommon side effects
title_full_unstemmed Sodium valproate: cacosmia and dysgeusia as uncommon side effects
title_short Sodium valproate: cacosmia and dysgeusia as uncommon side effects
title_sort sodium valproate: cacosmia and dysgeusia as uncommon side effects
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660243/
https://www.ncbi.nlm.nih.gov/pubmed/38026105
http://dx.doi.org/10.22551/2023.41.1004.10265
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