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Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot
Small fiber neuropathy (SFN) has not been reported after the third dose of BNT162b2 in a previously healthy vaccinee. A 44-year-old previously healthy female developed pain and sensory disturbances in varying locations after the third BNT162b2 dose. Additionally, she developed recurrent tinnitus, he...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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UMF “Gr. T. Popa” Iasi Publishing House
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660248/ https://www.ncbi.nlm.nih.gov/pubmed/38026108 http://dx.doi.org/10.22551/2023.41.1004.10264 |
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author | Finsterer, Josef |
author_facet | Finsterer, Josef |
author_sort | Finsterer, Josef |
collection | PubMed |
description | Small fiber neuropathy (SFN) has not been reported after the third dose of BNT162b2 in a previously healthy vaccinee. A 44-year-old previously healthy female developed pain and sensory disturbances in varying locations after the third BNT162b2 dose. Additionally, she developed recurrent tinnitus, headaches, arthralgia, neck stiffness, and motor dysfunction. A skin biopsy five months after symptom onset revealed normal intra-epidermal nerve fiber density (IENFD) but reduced sweat gland nerve fiber density. She is intended for a first series of intravenous immunoglobulins. SARS-CoV-2 vaccinations may be complicated by SFN; the diagnosis SARS-CoV-2 vaccination SFN may be delayed; IENFD may be normal, but sweat gland nerve fiber density may document SFN; and full recovery after SFN cannot always be achieved quickly. |
format | Online Article Text |
id | pubmed-10660248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | UMF “Gr. T. Popa” Iasi Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-106602482023-11-21 Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot Finsterer, Josef Arch Clin Cases Case Report Small fiber neuropathy (SFN) has not been reported after the third dose of BNT162b2 in a previously healthy vaccinee. A 44-year-old previously healthy female developed pain and sensory disturbances in varying locations after the third BNT162b2 dose. Additionally, she developed recurrent tinnitus, headaches, arthralgia, neck stiffness, and motor dysfunction. A skin biopsy five months after symptom onset revealed normal intra-epidermal nerve fiber density (IENFD) but reduced sweat gland nerve fiber density. She is intended for a first series of intravenous immunoglobulins. SARS-CoV-2 vaccinations may be complicated by SFN; the diagnosis SARS-CoV-2 vaccination SFN may be delayed; IENFD may be normal, but sweat gland nerve fiber density may document SFN; and full recovery after SFN cannot always be achieved quickly. UMF “Gr. T. Popa” Iasi Publishing House 2023-11-21 /pmc/articles/PMC10660248/ /pubmed/38026108 http://dx.doi.org/10.22551/2023.41.1004.10264 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Finsterer, Josef Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot |
title | Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot |
title_full | Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot |
title_fullStr | Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot |
title_full_unstemmed | Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot |
title_short | Small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third BNT162b2 shot |
title_sort | small fiber neuropathy with normal intra-epidermal nerve fiber density but reduced sweat gland density after third bnt162b2 shot |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660248/ https://www.ncbi.nlm.nih.gov/pubmed/38026108 http://dx.doi.org/10.22551/2023.41.1004.10264 |
work_keys_str_mv | AT finstererjosef smallfiberneuropathywithnormalintraepidermalnervefiberdensitybutreducedsweatglanddensityafterthirdbnt162b2shot |