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Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran

Background: Serum alkaline phosphatase (ALP) is an indicator of hepatobiliary disorders, such as metabolic syndrome (MetS). To assess the association between serum ALP levels and MetS, with or without non-alcoholic fatty liver disease (NAFLD), in a cohort study in northern Iran. Methods: Data from a...

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Autores principales: Sohrabi, Masoudreza, Aghapour, Sevil, Khoonsari, Mahmoodreza, Ajdarkosh, Hossein, Nobakht, Hossein, Zamani, Farhad, Nikkhah, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Association of Gastroerterology and Hepatology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660317/
https://www.ncbi.nlm.nih.gov/pubmed/38023461
http://dx.doi.org/10.34172/mejdd.2023.340
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author Sohrabi, Masoudreza
Aghapour, Sevil
Khoonsari, Mahmoodreza
Ajdarkosh, Hossein
Nobakht, Hossein
Zamani, Farhad
Nikkhah, Mehdi
author_facet Sohrabi, Masoudreza
Aghapour, Sevil
Khoonsari, Mahmoodreza
Ajdarkosh, Hossein
Nobakht, Hossein
Zamani, Farhad
Nikkhah, Mehdi
author_sort Sohrabi, Masoudreza
collection PubMed
description Background: Serum alkaline phosphatase (ALP) is an indicator of hepatobiliary disorders, such as metabolic syndrome (MetS). To assess the association between serum ALP levels and MetS, with or without non-alcoholic fatty liver disease (NAFLD), in a cohort study in northern Iran. Methods: Data from approximately 5257 subjects aged more than 18 years participating in the Amol cohort were used. We extracted the required data and investigated the correlation between liver enzyme levels and MetS. Multiple logistic regression analyses based on the serum ALP quartiles were performed. Results: Of them, 2860 were male with a mean age of 42.11±16.1 years. A positive linear trend was observed between serum ALP levels and the number of MetS components in both sexes. In both sexes, systolic blood pressure, waist circumferences, and high-density lipoprotein (HDL) had a significant association with ALP. After adjusting for age, both sexes with NAFLD showed an increased risk of developing MetS. The risk of NAFLD increased in individuals with>2nd quartile of ALP. Furthermore, higher ALP levels were associated with an increased risk of MetS in males (1.1014 [0.782–1.315]) and females (1.441 [1.085–1.913]). Conclusion: There is a significant association between serum ALP levels and MetS, independent of fatty liver changes, suggesting that this marker can be considered as a feasible predictor of MetS.
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spelling pubmed-106603172023-07-01 Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran Sohrabi, Masoudreza Aghapour, Sevil Khoonsari, Mahmoodreza Ajdarkosh, Hossein Nobakht, Hossein Zamani, Farhad Nikkhah, Mehdi Middle East J Dig Dis Original Article Background: Serum alkaline phosphatase (ALP) is an indicator of hepatobiliary disorders, such as metabolic syndrome (MetS). To assess the association between serum ALP levels and MetS, with or without non-alcoholic fatty liver disease (NAFLD), in a cohort study in northern Iran. Methods: Data from approximately 5257 subjects aged more than 18 years participating in the Amol cohort were used. We extracted the required data and investigated the correlation between liver enzyme levels and MetS. Multiple logistic regression analyses based on the serum ALP quartiles were performed. Results: Of them, 2860 were male with a mean age of 42.11±16.1 years. A positive linear trend was observed between serum ALP levels and the number of MetS components in both sexes. In both sexes, systolic blood pressure, waist circumferences, and high-density lipoprotein (HDL) had a significant association with ALP. After adjusting for age, both sexes with NAFLD showed an increased risk of developing MetS. The risk of NAFLD increased in individuals with>2nd quartile of ALP. Furthermore, higher ALP levels were associated with an increased risk of MetS in males (1.1014 [0.782–1.315]) and females (1.441 [1.085–1.913]). Conclusion: There is a significant association between serum ALP levels and MetS, independent of fatty liver changes, suggesting that this marker can be considered as a feasible predictor of MetS. Iranian Association of Gastroerterology and Hepatology 2023-07 2023-07-30 /pmc/articles/PMC10660317/ /pubmed/38023461 http://dx.doi.org/10.34172/mejdd.2023.340 Text en © 2023 Middle East Journal of Digestive Diseases https://creativecommons.org/licenses/by-nc-sa/4.0/ This work is published by Middle East Journal of Digestive Diseases as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sohrabi, Masoudreza
Aghapour, Sevil
Khoonsari, Mahmoodreza
Ajdarkosh, Hossein
Nobakht, Hossein
Zamani, Farhad
Nikkhah, Mehdi
Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran
title Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran
title_full Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran
title_fullStr Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran
title_full_unstemmed Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran
title_short Serum Alkaline Phosphate Level Associates with Metabolic Syndrome Components Regardless of Non-Alcoholic Fatty Liver; A Population-Based Study in Northern Iran
title_sort serum alkaline phosphate level associates with metabolic syndrome components regardless of non-alcoholic fatty liver; a population-based study in northern iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660317/
https://www.ncbi.nlm.nih.gov/pubmed/38023461
http://dx.doi.org/10.34172/mejdd.2023.340
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