Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia

UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co‐mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF‐TDs in leukemogenesis is yet to be elucidated; how...

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Autores principales: Harrop, Sean, Nguyen, Phillip C., Byrne, David, Wilson, Clarissa, Ryland, Georgina L., Nguyen, Tamia, Anderson, Mary Ann, Khaw, Seong Lin, Martin, Michelle, Tiong, Ing Soo, Sanij, Elaine, Blombery, Piers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660390/
https://www.ncbi.nlm.nih.gov/pubmed/38024622
http://dx.doi.org/10.1002/jha2.808
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author Harrop, Sean
Nguyen, Phillip C.
Byrne, David
Wilson, Clarissa
Ryland, Georgina L.
Nguyen, Tamia
Anderson, Mary Ann
Khaw, Seong Lin
Martin, Michelle
Tiong, Ing Soo
Sanij, Elaine
Blombery, Piers
author_facet Harrop, Sean
Nguyen, Phillip C.
Byrne, David
Wilson, Clarissa
Ryland, Georgina L.
Nguyen, Tamia
Anderson, Mary Ann
Khaw, Seong Lin
Martin, Michelle
Tiong, Ing Soo
Sanij, Elaine
Blombery, Piers
author_sort Harrop, Sean
collection PubMed
description UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co‐mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF‐TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF‐TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.
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spelling pubmed-106603902023-10-19 Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia Harrop, Sean Nguyen, Phillip C. Byrne, David Wilson, Clarissa Ryland, Georgina L. Nguyen, Tamia Anderson, Mary Ann Khaw, Seong Lin Martin, Michelle Tiong, Ing Soo Sanij, Elaine Blombery, Piers EJHaem Short Reports UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co‐mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF‐TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF‐TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity. John Wiley and Sons Inc. 2023-10-19 /pmc/articles/PMC10660390/ /pubmed/38024622 http://dx.doi.org/10.1002/jha2.808 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Short Reports
Harrop, Sean
Nguyen, Phillip C.
Byrne, David
Wilson, Clarissa
Ryland, Georgina L.
Nguyen, Tamia
Anderson, Mary Ann
Khaw, Seong Lin
Martin, Michelle
Tiong, Ing Soo
Sanij, Elaine
Blombery, Piers
Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
title Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
title_full Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
title_fullStr Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
title_full_unstemmed Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
title_short Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
title_sort persistence of ubtf tandem duplications in remission in acute myeloid leukaemia
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660390/
https://www.ncbi.nlm.nih.gov/pubmed/38024622
http://dx.doi.org/10.1002/jha2.808
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