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Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. It is not clear whether the metabolic consequences of chronic inflammation are involved. Biological disease-modifying anti-rheumatic drugs (bDMARDs) are highly efficient in the treatment of inflammation in RA. In this study,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660495/ https://www.ncbi.nlm.nih.gov/pubmed/37987275 http://dx.doi.org/10.3390/diseases11040164 |
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author | Macáková, Kristína Tekeľová, Mária Mlynáriková, Vanda Šebeková, Katarína Vlková, Barbora Celec, Peter Šteňová, Emöke |
author_facet | Macáková, Kristína Tekeľová, Mária Mlynáriková, Vanda Šebeková, Katarína Vlková, Barbora Celec, Peter Šteňová, Emöke |
author_sort | Macáková, Kristína |
collection | PubMed |
description | Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. It is not clear whether the metabolic consequences of chronic inflammation are involved. Biological disease-modifying anti-rheumatic drugs (bDMARDs) are highly efficient in the treatment of inflammation in RA. In this study, we aimed to describe the metabolic effects of anti-TNF-α treatment in RA patients. The clinical status of 16 patients was assessed using disease activity score-28 (DAS28) and C-reactive protein (CRP). Plasma samples were collected before treatment with anti-TNF-α treatment as well as after three and six months of treatment. Markers of lipid and glucose metabolism, as well as renal biomarkers, were assessed using standard biochemistry. ELISA was used for the quantification of insulin, leptin, and adiponectin. Although fasting insulin decreased by 14% at the end of the study, most of the analyzed parameters did not show any statistically or clinically significant dynamics. The exception was total bilirubin and cholesterol, which increased by 53% and 14%, respectively, after six months of treatment with anti-TNF-α treatment. Anti-TNF-α treatment did not induce major metabolic changes despite the strong anti-inflammatory and clinical symptoms of RA. Further studies will show whether longer observations are required for the detection of the metabolic effects of the anti-inflammatory treatment. Additional research is needed to understand the observed effect of bilirubin as an important endogenous antioxidant. |
format | Online Article Text |
id | pubmed-10660495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106604952023-11-09 Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis Macáková, Kristína Tekeľová, Mária Mlynáriková, Vanda Šebeková, Katarína Vlková, Barbora Celec, Peter Šteňová, Emöke Diseases Brief Report Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. It is not clear whether the metabolic consequences of chronic inflammation are involved. Biological disease-modifying anti-rheumatic drugs (bDMARDs) are highly efficient in the treatment of inflammation in RA. In this study, we aimed to describe the metabolic effects of anti-TNF-α treatment in RA patients. The clinical status of 16 patients was assessed using disease activity score-28 (DAS28) and C-reactive protein (CRP). Plasma samples were collected before treatment with anti-TNF-α treatment as well as after three and six months of treatment. Markers of lipid and glucose metabolism, as well as renal biomarkers, were assessed using standard biochemistry. ELISA was used for the quantification of insulin, leptin, and adiponectin. Although fasting insulin decreased by 14% at the end of the study, most of the analyzed parameters did not show any statistically or clinically significant dynamics. The exception was total bilirubin and cholesterol, which increased by 53% and 14%, respectively, after six months of treatment with anti-TNF-α treatment. Anti-TNF-α treatment did not induce major metabolic changes despite the strong anti-inflammatory and clinical symptoms of RA. Further studies will show whether longer observations are required for the detection of the metabolic effects of the anti-inflammatory treatment. Additional research is needed to understand the observed effect of bilirubin as an important endogenous antioxidant. MDPI 2023-11-09 /pmc/articles/PMC10660495/ /pubmed/37987275 http://dx.doi.org/10.3390/diseases11040164 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Macáková, Kristína Tekeľová, Mária Mlynáriková, Vanda Šebeková, Katarína Vlková, Barbora Celec, Peter Šteňová, Emöke Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis |
title | Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis |
title_full | Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis |
title_fullStr | Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis |
title_full_unstemmed | Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis |
title_short | Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis |
title_sort | metabolic effects of anti-tnf-α treatment in rheumatoid arthritis |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660495/ https://www.ncbi.nlm.nih.gov/pubmed/37987275 http://dx.doi.org/10.3390/diseases11040164 |
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