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A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients

To establish a nomogram for elderly patients with diffuse large B‐cell lymphoma (DLBCL) based on nutritional and imaging features. The data of 221 elderly pretreatment DLBCL patients were retrospectively analyzed. All cases were randomly separated into the training group and validation group. A nomo...

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Autores principales: Li, Maoqin, Lu, Haihao, Fan, Jiaoyang, Dai, Min, Su, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660607/
https://www.ncbi.nlm.nih.gov/pubmed/38024603
http://dx.doi.org/10.1002/jha2.794
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author Li, Maoqin
Lu, Haihao
Fan, Jiaoyang
Dai, Min
Su, Chang
author_facet Li, Maoqin
Lu, Haihao
Fan, Jiaoyang
Dai, Min
Su, Chang
author_sort Li, Maoqin
collection PubMed
description To establish a nomogram for elderly patients with diffuse large B‐cell lymphoma (DLBCL) based on nutritional and imaging features. The data of 221 elderly pretreatment DLBCL patients were retrospectively analyzed. All cases were randomly separated into the training group and validation group. A nomogram was built based on the results of multivariate analysis. A nomogram was established based on maximum standardized uptake value (SUVmax), geriatric nutritional risk index (GNRI), and lactate dehydrogenase. The concordance index (C‐index) of the nomogram was 0.772 for the training group and 0.729 for the validation group, and similar results were found in the area under the curve (AUC). The calibration curve showed favorable consistency between prediction and real survival. The decision curve analysis (DCA) also showed that the nomogram had favorable clinical effectiveness. The new risk‐stratification model divided patients into three groups with obvious survival. The C‐index and AUCs for the new model were greater than those of IPI and NCCN‐IPI. The DCA curve suggested that the new model had better clinical effectiveness than the IPI and NCCN‐IPI. The nomogram prognostic model based on SUVmax and GNRI performed superior to NCCN‐IPI and equal to IPI for risk stratification of elderly DLBCL patients.
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spelling pubmed-106606072023-09-23 A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients Li, Maoqin Lu, Haihao Fan, Jiaoyang Dai, Min Su, Chang EJHaem Haematologic Malignancy ‐ Lymphoid To establish a nomogram for elderly patients with diffuse large B‐cell lymphoma (DLBCL) based on nutritional and imaging features. The data of 221 elderly pretreatment DLBCL patients were retrospectively analyzed. All cases were randomly separated into the training group and validation group. A nomogram was built based on the results of multivariate analysis. A nomogram was established based on maximum standardized uptake value (SUVmax), geriatric nutritional risk index (GNRI), and lactate dehydrogenase. The concordance index (C‐index) of the nomogram was 0.772 for the training group and 0.729 for the validation group, and similar results were found in the area under the curve (AUC). The calibration curve showed favorable consistency between prediction and real survival. The decision curve analysis (DCA) also showed that the nomogram had favorable clinical effectiveness. The new risk‐stratification model divided patients into three groups with obvious survival. The C‐index and AUCs for the new model were greater than those of IPI and NCCN‐IPI. The DCA curve suggested that the new model had better clinical effectiveness than the IPI and NCCN‐IPI. The nomogram prognostic model based on SUVmax and GNRI performed superior to NCCN‐IPI and equal to IPI for risk stratification of elderly DLBCL patients. John Wiley and Sons Inc. 2023-09-23 /pmc/articles/PMC10660607/ /pubmed/38024603 http://dx.doi.org/10.1002/jha2.794 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Haematologic Malignancy ‐ Lymphoid
Li, Maoqin
Lu, Haihao
Fan, Jiaoyang
Dai, Min
Su, Chang
A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients
title A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients
title_full A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients
title_fullStr A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients
title_full_unstemmed A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients
title_short A nomogram prognostic model for diffuse large B‐cell lymphoma based on SUVmax and GNRI in elderly patients
title_sort nomogram prognostic model for diffuse large b‐cell lymphoma based on suvmax and gnri in elderly patients
topic Haematologic Malignancy ‐ Lymphoid
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660607/
https://www.ncbi.nlm.nih.gov/pubmed/38024603
http://dx.doi.org/10.1002/jha2.794
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