Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock

Diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T-cell lymphoma (AITL) are two subtypes of non-Hodgkin lymphoma (NHL). The simultaneous occurrence of DLBCL and AITL in a composite lymphoma is very rare, and there are no established treatment regimens. We present the case of an 85-year-o...

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Autores principales: Hariharan, Nisha, Kabadi, Alisha, Don, Michelle, Odish, Mazen, Heyman, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660698/
https://www.ncbi.nlm.nih.gov/pubmed/37987320
http://dx.doi.org/10.3390/hematolrep15040064
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author Hariharan, Nisha
Kabadi, Alisha
Don, Michelle
Odish, Mazen
Heyman, Benjamin
author_facet Hariharan, Nisha
Kabadi, Alisha
Don, Michelle
Odish, Mazen
Heyman, Benjamin
author_sort Hariharan, Nisha
collection PubMed
description Diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T-cell lymphoma (AITL) are two subtypes of non-Hodgkin lymphoma (NHL). The simultaneous occurrence of DLBCL and AITL in a composite lymphoma is very rare, and there are no established treatment regimens. We present the case of an 85-year-old male admitted to the intensive care unit with distributive shock, lymphocytosis, and lymphadenopathy, who was subsequently diagnosed with composite AITL and DLBCL, and treated with brentuximab vedotin (BV) and rituximab. To our knowledge, this is the first case of composite lymphoma presenting with distributive shock and treated with BV and rituximab, with successful resolution of shock.
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spelling pubmed-106606982023-11-16 Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock Hariharan, Nisha Kabadi, Alisha Don, Michelle Odish, Mazen Heyman, Benjamin Hematol Rep Case Report Diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T-cell lymphoma (AITL) are two subtypes of non-Hodgkin lymphoma (NHL). The simultaneous occurrence of DLBCL and AITL in a composite lymphoma is very rare, and there are no established treatment regimens. We present the case of an 85-year-old male admitted to the intensive care unit with distributive shock, lymphocytosis, and lymphadenopathy, who was subsequently diagnosed with composite AITL and DLBCL, and treated with brentuximab vedotin (BV) and rituximab. To our knowledge, this is the first case of composite lymphoma presenting with distributive shock and treated with BV and rituximab, with successful resolution of shock. MDPI 2023-11-16 /pmc/articles/PMC10660698/ /pubmed/37987320 http://dx.doi.org/10.3390/hematolrep15040064 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Hariharan, Nisha
Kabadi, Alisha
Don, Michelle
Odish, Mazen
Heyman, Benjamin
Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock
title Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock
title_full Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock
title_fullStr Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock
title_full_unstemmed Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock
title_short Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock
title_sort composite angioimmunoblastic t-cell lymphoma and diffuse large b-cell lymphoma presenting with distributive shock
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660698/
https://www.ncbi.nlm.nih.gov/pubmed/37987320
http://dx.doi.org/10.3390/hematolrep15040064
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