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Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer

Special populations, particularly pregnant women, are uniquely susceptible to infectious diseases due to alterations in their immunological, respiratory, and cardiovascular systems during gestation. Influenza infections during the perinatal period have been associated with more severe maternal and p...

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Autores principales: Taskou, Chrysoula, Sarantaki, Antigoni, Georgakopoulou, Vasiliki Ε., Spyratos, Gerasimos A., Drossos, Panagiotis V., Daskalakis, Georgios, Beloukas, Apostolos, Lykeridou, Aikaterini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660699/
https://www.ncbi.nlm.nih.gov/pubmed/37987278
http://dx.doi.org/10.3390/diseases11040166
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author Taskou, Chrysoula
Sarantaki, Antigoni
Georgakopoulou, Vasiliki Ε.
Spyratos, Gerasimos A.
Drossos, Panagiotis V.
Daskalakis, Georgios
Beloukas, Apostolos
Lykeridou, Aikaterini
author_facet Taskou, Chrysoula
Sarantaki, Antigoni
Georgakopoulou, Vasiliki Ε.
Spyratos, Gerasimos A.
Drossos, Panagiotis V.
Daskalakis, Georgios
Beloukas, Apostolos
Lykeridou, Aikaterini
author_sort Taskou, Chrysoula
collection PubMed
description Special populations, particularly pregnant women, are uniquely susceptible to infectious diseases due to alterations in their immunological, respiratory, and cardiovascular systems during gestation. Influenza infections during the perinatal period have been associated with more severe maternal and perinatal outcomes, underscoring the critical importance of vaccination data for pregnant women. According to the World Health Organization (WHO), all pregnant women and those of childbearing age should receive the inactivated influenza vaccine, irrespective of their pregnancy stage. This study aimed to elucidate factors influencing neonatal antibody presence following maternal influenza vaccination. Conducted through convenience sampling in Athens, Greece, this study involved 78 pregnant women who received flu vaccinations. The participants completed questionnaires covering demographics, obstetric history, attitudes toward influenza vaccination, and knowledge about the influenza virus and pregnancy vaccination. Blood samples were collected from 83 neonates to assess IgG antibody presence. Five of the surveyed women had twin pregnancies. The statistical analysis employed IBM SPSS-Statistics version 26.0. This study revealed the presence of positive influenza A and B antibodies in neonates following maternal immunization. Furthermore, it identified factors such as the gestational week and timing of vaccination during pregnancy that influenced the transfer of antibodies from mother to fetus. These findings offer valuable insights for healthcare professionals to provide informed recommendations on influenza vaccination during pregnancy and empower expectant mothers to make informed decisions about the benefits of immunization.
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spelling pubmed-106606992023-11-10 Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer Taskou, Chrysoula Sarantaki, Antigoni Georgakopoulou, Vasiliki Ε. Spyratos, Gerasimos A. Drossos, Panagiotis V. Daskalakis, Georgios Beloukas, Apostolos Lykeridou, Aikaterini Diseases Article Special populations, particularly pregnant women, are uniquely susceptible to infectious diseases due to alterations in their immunological, respiratory, and cardiovascular systems during gestation. Influenza infections during the perinatal period have been associated with more severe maternal and perinatal outcomes, underscoring the critical importance of vaccination data for pregnant women. According to the World Health Organization (WHO), all pregnant women and those of childbearing age should receive the inactivated influenza vaccine, irrespective of their pregnancy stage. This study aimed to elucidate factors influencing neonatal antibody presence following maternal influenza vaccination. Conducted through convenience sampling in Athens, Greece, this study involved 78 pregnant women who received flu vaccinations. The participants completed questionnaires covering demographics, obstetric history, attitudes toward influenza vaccination, and knowledge about the influenza virus and pregnancy vaccination. Blood samples were collected from 83 neonates to assess IgG antibody presence. Five of the surveyed women had twin pregnancies. The statistical analysis employed IBM SPSS-Statistics version 26.0. This study revealed the presence of positive influenza A and B antibodies in neonates following maternal immunization. Furthermore, it identified factors such as the gestational week and timing of vaccination during pregnancy that influenced the transfer of antibodies from mother to fetus. These findings offer valuable insights for healthcare professionals to provide informed recommendations on influenza vaccination during pregnancy and empower expectant mothers to make informed decisions about the benefits of immunization. MDPI 2023-11-10 /pmc/articles/PMC10660699/ /pubmed/37987278 http://dx.doi.org/10.3390/diseases11040166 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taskou, Chrysoula
Sarantaki, Antigoni
Georgakopoulou, Vasiliki Ε.
Spyratos, Gerasimos A.
Drossos, Panagiotis V.
Daskalakis, Georgios
Beloukas, Apostolos
Lykeridou, Aikaterini
Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer
title Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer
title_full Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer
title_fullStr Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer
title_full_unstemmed Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer
title_short Assessing the Presence of IgG Antibodies against Influenza Viruses in Neonates after Maternal Vaccination and Factors That May Affect the Transplacental Transfer
title_sort assessing the presence of igg antibodies against influenza viruses in neonates after maternal vaccination and factors that may affect the transplacental transfer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660699/
https://www.ncbi.nlm.nih.gov/pubmed/37987278
http://dx.doi.org/10.3390/diseases11040166
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