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Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital

(1) Background: Drug–drug interactions (DDIs) possess the potential to lead to a range of clinically significant consequences in the older population. (2) Aims: To investigate the prevalence and associated factors of DDIs among older patients within an outpatient setting of a university hospital. (3...

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Autores principales: Wannawichate, Tippayavadee, Limpawattana, Panita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660705/
https://www.ncbi.nlm.nih.gov/pubmed/37987471
http://dx.doi.org/10.3390/geriatrics8060111
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author Wannawichate, Tippayavadee
Limpawattana, Panita
author_facet Wannawichate, Tippayavadee
Limpawattana, Panita
author_sort Wannawichate, Tippayavadee
collection PubMed
description (1) Background: Drug–drug interactions (DDIs) possess the potential to lead to a range of clinically significant consequences in the older population. (2) Aims: To investigate the prevalence and associated factors of DDIs among older patients within an outpatient setting of a university hospital. (3) Methods: This is a descriptive analysis of patients aged ≥65 years, who received a minimum of two medications. The electronic medical records were obtained from the outpatient clinic of a tertiary care hospital between November 2021 and November 2022. The outcomes were analyzed using descriptive and regression analysis. (4) Results: The study enrolled 10,877 patients, with a mean age of 74.3 ± 6.8 years. The prevalence of major DDI was 36.8%. Factors associated with major DDI were age (odds ratio [OR] 1.03), female sex (OR 1.23), polypharmacy (OR 2.27–13.78), metabolic disease (OR 1.89), psychiatric disorder (OR 1.79), cardiovascular disease (OR 1.51), musculoskeletal disease (OR 1.37), central nervous system disease (OR 1.24), and tuberculosis (OR 0.18). There was a significant difference observed in the primary healthcare facilities for emergency medicine (OR 1.72), orthopedics (OR 1.36), internal medicine (OR 1.29), and radiology (OR 0.45). (5) Conclusions: Major DDI was prevalent among older patients receiving care at outpatient settings. Several factors linked to major DDIs were identified. Developing appropriate strategies to improve the prescription process and avoid any missed interactions with geriatric patients is recommended.
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spelling pubmed-106607052023-11-14 Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital Wannawichate, Tippayavadee Limpawattana, Panita Geriatrics (Basel) Article (1) Background: Drug–drug interactions (DDIs) possess the potential to lead to a range of clinically significant consequences in the older population. (2) Aims: To investigate the prevalence and associated factors of DDIs among older patients within an outpatient setting of a university hospital. (3) Methods: This is a descriptive analysis of patients aged ≥65 years, who received a minimum of two medications. The electronic medical records were obtained from the outpatient clinic of a tertiary care hospital between November 2021 and November 2022. The outcomes were analyzed using descriptive and regression analysis. (4) Results: The study enrolled 10,877 patients, with a mean age of 74.3 ± 6.8 years. The prevalence of major DDI was 36.8%. Factors associated with major DDI were age (odds ratio [OR] 1.03), female sex (OR 1.23), polypharmacy (OR 2.27–13.78), metabolic disease (OR 1.89), psychiatric disorder (OR 1.79), cardiovascular disease (OR 1.51), musculoskeletal disease (OR 1.37), central nervous system disease (OR 1.24), and tuberculosis (OR 0.18). There was a significant difference observed in the primary healthcare facilities for emergency medicine (OR 1.72), orthopedics (OR 1.36), internal medicine (OR 1.29), and radiology (OR 0.45). (5) Conclusions: Major DDI was prevalent among older patients receiving care at outpatient settings. Several factors linked to major DDIs were identified. Developing appropriate strategies to improve the prescription process and avoid any missed interactions with geriatric patients is recommended. MDPI 2023-11-14 /pmc/articles/PMC10660705/ /pubmed/37987471 http://dx.doi.org/10.3390/geriatrics8060111 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wannawichate, Tippayavadee
Limpawattana, Panita
Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital
title Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital
title_full Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital
title_fullStr Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital
title_full_unstemmed Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital
title_short Potential Drug–Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital
title_sort potential drug–drug interactions and related factors among geriatric outpatients of a tertiary care hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660705/
https://www.ncbi.nlm.nih.gov/pubmed/37987471
http://dx.doi.org/10.3390/geriatrics8060111
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