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Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions
Chronic pain is a health problem that affects the ability to work and perform other activities, and it generally worsens over time. Understanding the complex pain interaction with brain circuits could help predict which patients are at risk of developing central dysfunctions. Increasing evidence fro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660716/ https://www.ncbi.nlm.nih.gov/pubmed/37987455 http://dx.doi.org/10.3390/neurolint15040082 |
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author | Pereira, Ana Raquel Alemi, Mobina Cerqueira-Nunes, Mariana Monteiro, Clara Galhardo, Vasco Cardoso-Cruz, Helder |
author_facet | Pereira, Ana Raquel Alemi, Mobina Cerqueira-Nunes, Mariana Monteiro, Clara Galhardo, Vasco Cardoso-Cruz, Helder |
author_sort | Pereira, Ana Raquel |
collection | PubMed |
description | Chronic pain is a health problem that affects the ability to work and perform other activities, and it generally worsens over time. Understanding the complex pain interaction with brain circuits could help predict which patients are at risk of developing central dysfunctions. Increasing evidence from preclinical and clinical studies suggests that aberrant activity of the lateral habenula (LHb) is associated with depressive symptoms characterized by excessive negative focus, leading to high-level cognitive dysfunctions. The primary output region of the LHb is the ventral tegmental area (VTA), through a bidirectional connection. Recently, there has been growing interest in the complex interactions between the LHb and VTA, particularly regarding their crucial roles in behavior regulation and their potential involvement in the pathological impact of chronic pain on cognitive functions. In this review, we briefly discuss the structural and functional roles of the LHb–VTA microcircuit and their impact on cognition and mood disorders in order to support future studies addressing brain plasticity during chronic pain conditions. |
format | Online Article Text |
id | pubmed-10660716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106607162023-10-27 Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions Pereira, Ana Raquel Alemi, Mobina Cerqueira-Nunes, Mariana Monteiro, Clara Galhardo, Vasco Cardoso-Cruz, Helder Neurol Int Review Chronic pain is a health problem that affects the ability to work and perform other activities, and it generally worsens over time. Understanding the complex pain interaction with brain circuits could help predict which patients are at risk of developing central dysfunctions. Increasing evidence from preclinical and clinical studies suggests that aberrant activity of the lateral habenula (LHb) is associated with depressive symptoms characterized by excessive negative focus, leading to high-level cognitive dysfunctions. The primary output region of the LHb is the ventral tegmental area (VTA), through a bidirectional connection. Recently, there has been growing interest in the complex interactions between the LHb and VTA, particularly regarding their crucial roles in behavior regulation and their potential involvement in the pathological impact of chronic pain on cognitive functions. In this review, we briefly discuss the structural and functional roles of the LHb–VTA microcircuit and their impact on cognition and mood disorders in order to support future studies addressing brain plasticity during chronic pain conditions. MDPI 2023-10-27 /pmc/articles/PMC10660716/ /pubmed/37987455 http://dx.doi.org/10.3390/neurolint15040082 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pereira, Ana Raquel Alemi, Mobina Cerqueira-Nunes, Mariana Monteiro, Clara Galhardo, Vasco Cardoso-Cruz, Helder Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions |
title | Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions |
title_full | Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions |
title_fullStr | Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions |
title_full_unstemmed | Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions |
title_short | Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions |
title_sort | dynamics of lateral habenula–ventral tegmental area microcircuit on pain-related cognitive dysfunctions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660716/ https://www.ncbi.nlm.nih.gov/pubmed/37987455 http://dx.doi.org/10.3390/neurolint15040082 |
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