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Eosinophilic Annular Erythema Responding to Doxycycline

Eosinophilic annular erythema (EAE) is a rare skin disease characterized by relapsing and remitting pruritic, annular erythematous plaques and tissue eosinophilia. A 39-year-old male presented with a mildly pruritic, relapsing, and remitting urticarial rash. A biopsy revealed superficial and deep pe...

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Detalles Bibliográficos
Autores principales: Young, Jade N, Chung, Jina, Fett, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660796/
https://www.ncbi.nlm.nih.gov/pubmed/38022231
http://dx.doi.org/10.7759/cureus.47478
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author Young, Jade N
Chung, Jina
Fett, Nicole
author_facet Young, Jade N
Chung, Jina
Fett, Nicole
author_sort Young, Jade N
collection PubMed
description Eosinophilic annular erythema (EAE) is a rare skin disease characterized by relapsing and remitting pruritic, annular erythematous plaques and tissue eosinophilia. A 39-year-old male presented with a mildly pruritic, relapsing, and remitting urticarial rash. A biopsy revealed superficial and deep perivascular dermatitis with numerous eosinophils and some neutrophils, with an absence of flame figures. Based on clinical and histopathologic findings, the patient was given a diagnosis of eosinophilic annular erythema. Treatment was initiated with doxycycline 100 mg twice daily. The patient reported substantial improvement at three months and sustained clearance at one year, remaining on doxycycline well tolerated throughout. To our knowledge, no cases of EAE improving with doxycycline have been reported in the literature and, thus, our findings highlight a potential new therapy to consider in a patient with EAE.
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spelling pubmed-106607962023-10-22 Eosinophilic Annular Erythema Responding to Doxycycline Young, Jade N Chung, Jina Fett, Nicole Cureus Dermatology Eosinophilic annular erythema (EAE) is a rare skin disease characterized by relapsing and remitting pruritic, annular erythematous plaques and tissue eosinophilia. A 39-year-old male presented with a mildly pruritic, relapsing, and remitting urticarial rash. A biopsy revealed superficial and deep perivascular dermatitis with numerous eosinophils and some neutrophils, with an absence of flame figures. Based on clinical and histopathologic findings, the patient was given a diagnosis of eosinophilic annular erythema. Treatment was initiated with doxycycline 100 mg twice daily. The patient reported substantial improvement at three months and sustained clearance at one year, remaining on doxycycline well tolerated throughout. To our knowledge, no cases of EAE improving with doxycycline have been reported in the literature and, thus, our findings highlight a potential new therapy to consider in a patient with EAE. Cureus 2023-10-22 /pmc/articles/PMC10660796/ /pubmed/38022231 http://dx.doi.org/10.7759/cureus.47478 Text en Copyright © 2023, Young et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Young, Jade N
Chung, Jina
Fett, Nicole
Eosinophilic Annular Erythema Responding to Doxycycline
title Eosinophilic Annular Erythema Responding to Doxycycline
title_full Eosinophilic Annular Erythema Responding to Doxycycline
title_fullStr Eosinophilic Annular Erythema Responding to Doxycycline
title_full_unstemmed Eosinophilic Annular Erythema Responding to Doxycycline
title_short Eosinophilic Annular Erythema Responding to Doxycycline
title_sort eosinophilic annular erythema responding to doxycycline
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660796/
https://www.ncbi.nlm.nih.gov/pubmed/38022231
http://dx.doi.org/10.7759/cureus.47478
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