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Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder

The relationship between depression and insomnia is bidirectional and both conditions need to be treated adequately, especially in a vulnerable neurodevelopmental stage of adolescence. This study aimed to evaluate the effects of antidepressant treatment using vortioxetine (VOR) on the sleep architec...

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Autores principales: Mlyncekova, Zuzana, Hutka, Peter, Visnovcova, Zuzana, Ferencova, Nikola, Kovacova, Veronika, Macejova, Andrea, Tonhajzerova, Ingrid, Ondrejka, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660849/
https://www.ncbi.nlm.nih.gov/pubmed/37987393
http://dx.doi.org/10.3390/clockssleep5040042
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author Mlyncekova, Zuzana
Hutka, Peter
Visnovcova, Zuzana
Ferencova, Nikola
Kovacova, Veronika
Macejova, Andrea
Tonhajzerova, Ingrid
Ondrejka, Igor
author_facet Mlyncekova, Zuzana
Hutka, Peter
Visnovcova, Zuzana
Ferencova, Nikola
Kovacova, Veronika
Macejova, Andrea
Tonhajzerova, Ingrid
Ondrejka, Igor
author_sort Mlyncekova, Zuzana
collection PubMed
description The relationship between depression and insomnia is bidirectional and both conditions need to be treated adequately, especially in a vulnerable neurodevelopmental stage of adolescence. This study aimed to evaluate the effects of antidepressant treatment using vortioxetine (VOR) on the sleep architecture of depressed adolescents by using video-polysomnography (v-PSG), which has not been researched before. The v-PSG was performed on 30 adolescent in-patients (mean age of 15.0 years ± 1.5 SD, 21 girls) treated with VOR (dosage of 10/15/20 mg/day) administered orally once a day, before and after VOR treatment. The evaluated parameters were conventional sleep parameters, sleep fragmentation parameters, and selected spectral power indices. Symptoms of depression and insomnia before and after the treatment period were evaluated using valid and reliable questionnaires (the Children´s Depression Inventory and the Athens Insomnia Scale). Depressed adolescents showed higher REM latency and decreased REM sleep percentage after treatment than before the treatment period (p = 0.005, p = 0.009, respectively). Our study revealed REM suppression (increased REM latency and reduced REM sleep percentage), indicating altered sleep architecture as a potential result of VOR treatment, which seems to be dose-dependent.
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spelling pubmed-106608492023-10-24 Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder Mlyncekova, Zuzana Hutka, Peter Visnovcova, Zuzana Ferencova, Nikola Kovacova, Veronika Macejova, Andrea Tonhajzerova, Ingrid Ondrejka, Igor Clocks Sleep Article The relationship between depression and insomnia is bidirectional and both conditions need to be treated adequately, especially in a vulnerable neurodevelopmental stage of adolescence. This study aimed to evaluate the effects of antidepressant treatment using vortioxetine (VOR) on the sleep architecture of depressed adolescents by using video-polysomnography (v-PSG), which has not been researched before. The v-PSG was performed on 30 adolescent in-patients (mean age of 15.0 years ± 1.5 SD, 21 girls) treated with VOR (dosage of 10/15/20 mg/day) administered orally once a day, before and after VOR treatment. The evaluated parameters were conventional sleep parameters, sleep fragmentation parameters, and selected spectral power indices. Symptoms of depression and insomnia before and after the treatment period were evaluated using valid and reliable questionnaires (the Children´s Depression Inventory and the Athens Insomnia Scale). Depressed adolescents showed higher REM latency and decreased REM sleep percentage after treatment than before the treatment period (p = 0.005, p = 0.009, respectively). Our study revealed REM suppression (increased REM latency and reduced REM sleep percentage), indicating altered sleep architecture as a potential result of VOR treatment, which seems to be dose-dependent. MDPI 2023-10-24 /pmc/articles/PMC10660849/ /pubmed/37987393 http://dx.doi.org/10.3390/clockssleep5040042 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mlyncekova, Zuzana
Hutka, Peter
Visnovcova, Zuzana
Ferencova, Nikola
Kovacova, Veronika
Macejova, Andrea
Tonhajzerova, Ingrid
Ondrejka, Igor
Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder
title Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder
title_full Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder
title_fullStr Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder
title_full_unstemmed Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder
title_short Effects of Vortioxetine on Sleep Architecture of Adolescents with Major Depressive Disorder
title_sort effects of vortioxetine on sleep architecture of adolescents with major depressive disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660849/
https://www.ncbi.nlm.nih.gov/pubmed/37987393
http://dx.doi.org/10.3390/clockssleep5040042
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