Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group

One approach to enhance the bioavailability and half-life of peptides in vivo is through N-methylation of one or more of the amino acids within the peptide sequence. However, commercially available Fmoc-N-Me-AA-OHs are limited and often expensive. In this study, a solid-phase synthesis method for Fm...

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Detalles Bibliográficos
Autores principales: Román, Tanya, Acosta, Gerardo, Cárdenas, Constanza, de la Torre, Beatriz G., Guzmán, Fanny, Albericio, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660853/
https://www.ncbi.nlm.nih.gov/pubmed/37987357
http://dx.doi.org/10.3390/mps6060110

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