Cargando…

Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems

INTRODUCTION: Antipsychotic drugs are widely prescribed for schizophrenia and other mental disorders. They are critical in the pharmacological management of severe psychotic disorder. The adverse effects of antipsychotics are common, with a potential negative impact on adherence and engagement. Desp...

Descripción completa

Detalles Bibliográficos
Autores principales: El Moussaoui, N., Tounsi, A., Bahetta, S., Belbachir, S., Ouanass, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660869/
http://dx.doi.org/10.1192/j.eurpsy.2023.1315
_version_ 1785137850527776768
author El Moussaoui, N.
Tounsi, A.
Bahetta, S.
Belbachir, S.
Ouanass, A.
author_facet El Moussaoui, N.
Tounsi, A.
Bahetta, S.
Belbachir, S.
Ouanass, A.
author_sort El Moussaoui, N.
collection PubMed
description INTRODUCTION: Antipsychotic drugs are widely prescribed for schizophrenia and other mental disorders. They are critical in the pharmacological management of severe psychotic disorder. The adverse effects of antipsychotics are common, with a potential negative impact on adherence and engagement. Despite this, the scientific study of the prevalence of adverse antipsychotic effects is a neglected area. OBJECTIVES: We aim to identify the prevalence of nine clinically important categories of antipsychotic adverse effects, namely: extrapyramidal symptoms; sedation; weight gain; type II diabetes; hyperprolactinaemia; metabolic syndrome, dyslipidaemia; sexual dysfunction; and cardiovascular effects METHODS: This is a prospective, observational, cross-sectional study, carried out in Ar-razi hospital in Salé evaluating side effects in patients hospitalized and treated with antipsychotics within 3 months. RESULTS: In total, antipsychotic polypharmacy was associated with increased frequency of adverse effects, and a longer duration of treatment is associated with greater severity; clozapine was more strongly associated with metabolic disturbance than other antipsychotics in three studies and olanzapine was associated with the most weight gain in three studies; hyperprolactinemia was more common in women than men, but more men noted sexual dysfunction than women; CONCLUSIONS: Antipsychotic adverse effects are diverse and frequently experienced, but are not often systematically assessed. There is a need for further scientific study concerning the management of these side effects. DISCLOSURE OF INTEREST: None Declared
format Online
Article
Text
id pubmed-10660869
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-106608692023-07-19 Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems El Moussaoui, N. Tounsi, A. Bahetta, S. Belbachir, S. Ouanass, A. Eur Psychiatry Abstract INTRODUCTION: Antipsychotic drugs are widely prescribed for schizophrenia and other mental disorders. They are critical in the pharmacological management of severe psychotic disorder. The adverse effects of antipsychotics are common, with a potential negative impact on adherence and engagement. Despite this, the scientific study of the prevalence of adverse antipsychotic effects is a neglected area. OBJECTIVES: We aim to identify the prevalence of nine clinically important categories of antipsychotic adverse effects, namely: extrapyramidal symptoms; sedation; weight gain; type II diabetes; hyperprolactinaemia; metabolic syndrome, dyslipidaemia; sexual dysfunction; and cardiovascular effects METHODS: This is a prospective, observational, cross-sectional study, carried out in Ar-razi hospital in Salé evaluating side effects in patients hospitalized and treated with antipsychotics within 3 months. RESULTS: In total, antipsychotic polypharmacy was associated with increased frequency of adverse effects, and a longer duration of treatment is associated with greater severity; clozapine was more strongly associated with metabolic disturbance than other antipsychotics in three studies and olanzapine was associated with the most weight gain in three studies; hyperprolactinemia was more common in women than men, but more men noted sexual dysfunction than women; CONCLUSIONS: Antipsychotic adverse effects are diverse and frequently experienced, but are not often systematically assessed. There is a need for further scientific study concerning the management of these side effects. DISCLOSURE OF INTEREST: None Declared Cambridge University Press 2023-07-19 /pmc/articles/PMC10660869/ http://dx.doi.org/10.1192/j.eurpsy.2023.1315 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
El Moussaoui, N.
Tounsi, A.
Bahetta, S.
Belbachir, S.
Ouanass, A.
Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems
title Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems
title_full Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems
title_fullStr Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems
title_full_unstemmed Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems
title_short Prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems
title_sort prevalence of antipsychotic use and associated adverse effects in moroccan with mental health problems
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660869/
http://dx.doi.org/10.1192/j.eurpsy.2023.1315
work_keys_str_mv AT elmoussaouin prevalenceofantipsychoticuseandassociatedadverseeffectsinmoroccanwithmentalhealthproblems
AT tounsia prevalenceofantipsychoticuseandassociatedadverseeffectsinmoroccanwithmentalhealthproblems
AT bahettas prevalenceofantipsychoticuseandassociatedadverseeffectsinmoroccanwithmentalhealthproblems
AT belbachirs prevalenceofantipsychoticuseandassociatedadverseeffectsinmoroccanwithmentalhealthproblems
AT ouanassa prevalenceofantipsychoticuseandassociatedadverseeffectsinmoroccanwithmentalhealthproblems