Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline

[Image: see text] Bedaquiline (BDQ) is an important drug for treating multidrug-resistant tuberculosis (MDR-TB), a worldwide disease that causes more than 1.6 million deaths yearly. The current synthetic strategy adopted by the manufacturers to assemble this molecule relies on a nucleophilic additio...

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Detalles Bibliográficos
Autores principales: Robey, Juliana M. S., Maity, Sanjay, Aleshire, Sarah L., Ghosh, Angshuman, Yadaw, Ajay K., Roy, Subho, Mear, Sarah Jane, Jamison, Timothy F., Sirasani, Gopal, Senanayake, Chris H., Stringham, Rodger W., Gupton, B. Frank, Donsbach, Kai O., Nelson, Ryan C., Shanahan, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661061/
https://www.ncbi.nlm.nih.gov/pubmed/38025988
http://dx.doi.org/10.1021/acs.oprd.3c00287

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