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Lipid Disturbances in Breast Cancer Patients during Chemotherapy
Breast cancer is the most common cancer in women. Cardiovascular diseases are common complications after chemotherapy due to the effect of the drug on lipid levels. This study aimed to explore the changes in lipid profiles in patients with breast cancer under chemotherapy. Methods: In this prospecti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661266/ https://www.ncbi.nlm.nih.gov/pubmed/37987405 http://dx.doi.org/10.3390/nursrep13040126 |
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author | Alimperti, Aikaterini Alikari, Victoria Tsironi, Maria Rojas Gil, Andrea Paola Papageorgiou, Dimitrios Kolovos, Petros Panagiotou, Aspasia Panoutsopoulos, George I. Lavdaniti, Maria Zyga, Sofia |
author_facet | Alimperti, Aikaterini Alikari, Victoria Tsironi, Maria Rojas Gil, Andrea Paola Papageorgiou, Dimitrios Kolovos, Petros Panagiotou, Aspasia Panoutsopoulos, George I. Lavdaniti, Maria Zyga, Sofia |
author_sort | Alimperti, Aikaterini |
collection | PubMed |
description | Breast cancer is the most common cancer in women. Cardiovascular diseases are common complications after chemotherapy due to the effect of the drug on lipid levels. This study aimed to explore the changes in lipid profiles in patients with breast cancer under chemotherapy. Methods: In this prospective study, 50 patients with breast cancer participated. Three biochemical–lipid hematological tests were performed: total cholesterol (TC), triglycerides (TGs), High-Density Lipoprotein (HDL-C), and Low-Density Lipoprotein (LDL-C) before initiation (pre-chemotherapy), at the start (first follow-up), and at the completion (second follow-up) of the first cycle of chemotherapy. Statistical significance was set at p < 0.05. Analyses were conducted using SPSS Statistical Software (version 22.0). Results: Mean TC values increased significantly at second follow-up. TGs values decreased significantly from first to second follow-up. HDL-C was significantly lower at first follow-up compared with pre-chemotherapy and was similar to the pre-chemotherapy levels at second follow-up. LDL-C values were significantly higher at second follow-up compared with pre-chemotherapy measurement. Significantly positive correlations of BMI with pre-chemotherapy LDL-C, first follow-up TC, first follow-up LDL-C, second follow-up TC, and second follow-up LDL-C were found. Conclusions: There is a statistically significant increase in the levels of TC and LDL-C in breast cancer patients during chemotherapy. This study was not registered. |
format | Online Article Text |
id | pubmed-10661266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106612662023-10-25 Lipid Disturbances in Breast Cancer Patients during Chemotherapy Alimperti, Aikaterini Alikari, Victoria Tsironi, Maria Rojas Gil, Andrea Paola Papageorgiou, Dimitrios Kolovos, Petros Panagiotou, Aspasia Panoutsopoulos, George I. Lavdaniti, Maria Zyga, Sofia Nurs Rep Article Breast cancer is the most common cancer in women. Cardiovascular diseases are common complications after chemotherapy due to the effect of the drug on lipid levels. This study aimed to explore the changes in lipid profiles in patients with breast cancer under chemotherapy. Methods: In this prospective study, 50 patients with breast cancer participated. Three biochemical–lipid hematological tests were performed: total cholesterol (TC), triglycerides (TGs), High-Density Lipoprotein (HDL-C), and Low-Density Lipoprotein (LDL-C) before initiation (pre-chemotherapy), at the start (first follow-up), and at the completion (second follow-up) of the first cycle of chemotherapy. Statistical significance was set at p < 0.05. Analyses were conducted using SPSS Statistical Software (version 22.0). Results: Mean TC values increased significantly at second follow-up. TGs values decreased significantly from first to second follow-up. HDL-C was significantly lower at first follow-up compared with pre-chemotherapy and was similar to the pre-chemotherapy levels at second follow-up. LDL-C values were significantly higher at second follow-up compared with pre-chemotherapy measurement. Significantly positive correlations of BMI with pre-chemotherapy LDL-C, first follow-up TC, first follow-up LDL-C, second follow-up TC, and second follow-up LDL-C were found. Conclusions: There is a statistically significant increase in the levels of TC and LDL-C in breast cancer patients during chemotherapy. This study was not registered. MDPI 2023-10-25 /pmc/articles/PMC10661266/ /pubmed/37987405 http://dx.doi.org/10.3390/nursrep13040126 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alimperti, Aikaterini Alikari, Victoria Tsironi, Maria Rojas Gil, Andrea Paola Papageorgiou, Dimitrios Kolovos, Petros Panagiotou, Aspasia Panoutsopoulos, George I. Lavdaniti, Maria Zyga, Sofia Lipid Disturbances in Breast Cancer Patients during Chemotherapy |
title | Lipid Disturbances in Breast Cancer Patients during Chemotherapy |
title_full | Lipid Disturbances in Breast Cancer Patients during Chemotherapy |
title_fullStr | Lipid Disturbances in Breast Cancer Patients during Chemotherapy |
title_full_unstemmed | Lipid Disturbances in Breast Cancer Patients during Chemotherapy |
title_short | Lipid Disturbances in Breast Cancer Patients during Chemotherapy |
title_sort | lipid disturbances in breast cancer patients during chemotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661266/ https://www.ncbi.nlm.nih.gov/pubmed/37987405 http://dx.doi.org/10.3390/nursrep13040126 |
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