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Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature

KEY CLINICAL MESSAGE: Although increasing in number, cases of CVS are being frequently misdiagnosed and many are refractory to the available treatments. This paper draws attention to a timely consideration of this disorder upon suspicion and proposes rectal diazepam and cinnarizine as highly effecti...

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Autores principales: Togha, Mansoureh, Babaei, Mahsa, Jameie, Melika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661318/
https://www.ncbi.nlm.nih.gov/pubmed/38028097
http://dx.doi.org/10.1002/ccr3.8109
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author Togha, Mansoureh
Babaei, Mahsa
Jameie, Melika
author_facet Togha, Mansoureh
Babaei, Mahsa
Jameie, Melika
author_sort Togha, Mansoureh
collection PubMed
description KEY CLINICAL MESSAGE: Although increasing in number, cases of CVS are being frequently misdiagnosed and many are refractory to the available treatments. This paper draws attention to a timely consideration of this disorder upon suspicion and proposes rectal diazepam and cinnarizine as highly effective treatments in refractory cases of CVS. ABSTRACT: Cyclic vomiting syndrome (CVS) is a set of recurrent episodic attacks of nausea and vomiting. This is a migraine‐related disorder that mostly affects children. Several medications have been recommended for abortive and prophylactic treatment. Unfortunately, in some cases, the treatment is not completely effective and affects the quality of life of the sufferer. In this paper, we report on two cases of children experiencing refractory CVS attacks who were not responsive to recommended medications for acute phase and prophylaxis. This account highlights the efficacy of rectal diazepam for the acute phase of CVS and cinnarizine, an anti‐migraine and anti‐histamine agent, for prophylaxis of further attacks.
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spelling pubmed-106613182023-11-20 Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature Togha, Mansoureh Babaei, Mahsa Jameie, Melika Clin Case Rep Case Series KEY CLINICAL MESSAGE: Although increasing in number, cases of CVS are being frequently misdiagnosed and many are refractory to the available treatments. This paper draws attention to a timely consideration of this disorder upon suspicion and proposes rectal diazepam and cinnarizine as highly effective treatments in refractory cases of CVS. ABSTRACT: Cyclic vomiting syndrome (CVS) is a set of recurrent episodic attacks of nausea and vomiting. This is a migraine‐related disorder that mostly affects children. Several medications have been recommended for abortive and prophylactic treatment. Unfortunately, in some cases, the treatment is not completely effective and affects the quality of life of the sufferer. In this paper, we report on two cases of children experiencing refractory CVS attacks who were not responsive to recommended medications for acute phase and prophylaxis. This account highlights the efficacy of rectal diazepam for the acute phase of CVS and cinnarizine, an anti‐migraine and anti‐histamine agent, for prophylaxis of further attacks. John Wiley and Sons Inc. 2023-11-20 /pmc/articles/PMC10661318/ /pubmed/38028097 http://dx.doi.org/10.1002/ccr3.8109 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Togha, Mansoureh
Babaei, Mahsa
Jameie, Melika
Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature
title Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature
title_full Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature
title_fullStr Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature
title_full_unstemmed Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature
title_short Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature
title_sort good response to rectal diazepam in refractory cases of cyclic vomiting: a case‐series and review of the literature
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661318/
https://www.ncbi.nlm.nih.gov/pubmed/38028097
http://dx.doi.org/10.1002/ccr3.8109
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