Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia

Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 Japanese patients, including 55 with treatment-resistant sch...

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Autores principales: Kikuchi, Yuki, Yada, Yuji, Otsuka, Yuji, Ito, Fumiaki, Tanifuji, Hiroaki, Komatsu, Hiroshi, Tomita, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661360/
https://www.ncbi.nlm.nih.gov/pubmed/37985654
http://dx.doi.org/10.1038/s41537-023-00412-6
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author Kikuchi, Yuki
Yada, Yuji
Otsuka, Yuji
Ito, Fumiaki
Tanifuji, Hiroaki
Komatsu, Hiroshi
Tomita, Hiroaki
author_facet Kikuchi, Yuki
Yada, Yuji
Otsuka, Yuji
Ito, Fumiaki
Tanifuji, Hiroaki
Komatsu, Hiroshi
Tomita, Hiroaki
author_sort Kikuchi, Yuki
collection PubMed
description Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 Japanese patients, including 55 with treatment-resistant schizophrenia who developed clozapine-induced fever. Pearson’s product-moment correlation indicated a significant delay in the fever onset date with slower titration. Most fever onset cases occurred within 4 weeks, even with slow titration. Therefore, clinicians should remain vigilant in monitoring clozapine-induced fever within 4 weeks of clozapine initiation, regardless of the titration rate.
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spelling pubmed-106613602023-11-20 Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia Kikuchi, Yuki Yada, Yuji Otsuka, Yuji Ito, Fumiaki Tanifuji, Hiroaki Komatsu, Hiroshi Tomita, Hiroaki Schizophrenia (Heidelb) Brief Communication Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 Japanese patients, including 55 with treatment-resistant schizophrenia who developed clozapine-induced fever. Pearson’s product-moment correlation indicated a significant delay in the fever onset date with slower titration. Most fever onset cases occurred within 4 weeks, even with slow titration. Therefore, clinicians should remain vigilant in monitoring clozapine-induced fever within 4 weeks of clozapine initiation, regardless of the titration rate. Nature Publishing Group UK 2023-11-20 /pmc/articles/PMC10661360/ /pubmed/37985654 http://dx.doi.org/10.1038/s41537-023-00412-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Kikuchi, Yuki
Yada, Yuji
Otsuka, Yuji
Ito, Fumiaki
Tanifuji, Hiroaki
Komatsu, Hiroshi
Tomita, Hiroaki
Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia
title Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia
title_full Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia
title_fullStr Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia
title_full_unstemmed Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia
title_short Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia
title_sort slower clozapine titration is associated with delayed onset of clozapine-induced fever among japanese patients with schizophrenia
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661360/
https://www.ncbi.nlm.nih.gov/pubmed/37985654
http://dx.doi.org/10.1038/s41537-023-00412-6
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