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Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies

BACKGROUND: The co-occurrence of substance use disorder and mental disorder, known as dual diagnosis, has a distressingly high prevalence among individuals grappling with either of these conditions. Mood disorders, especially depression, constitute a substantial burden for People Who Inject Drugs (P...

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Autores principales: Moulis, Lionel, Le, Sao Mai, Hai, Vinh Vu, Huong, Duong Thi, Minh, Khuê Pham, Oanh, Khuat Thi Hai, Rapoud, Delphine, Quillet, Catherine, Thi, Tuyết Thanh Nham, Vallo, Roselyne, Hoang, Giang Thi, Moles, Jean-Pierre, Laureillard, Didier, Feelemyer, Jonathan, Des Jarlais, Don C., Michel, Laurent, Nagot, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661402/
https://www.ncbi.nlm.nih.gov/pubmed/38025448
http://dx.doi.org/10.3389/fpsyt.2023.1233844
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author Moulis, Lionel
Le, Sao Mai
Hai, Vinh Vu
Huong, Duong Thi
Minh, Khuê Pham
Oanh, Khuat Thi Hai
Rapoud, Delphine
Quillet, Catherine
Thi, Tuyết Thanh Nham
Vallo, Roselyne
Hoang, Giang Thi
Moles, Jean-Pierre
Laureillard, Didier
Feelemyer, Jonathan
Des Jarlais, Don C.
Michel, Laurent
Nagot, Nicolas
author_facet Moulis, Lionel
Le, Sao Mai
Hai, Vinh Vu
Huong, Duong Thi
Minh, Khuê Pham
Oanh, Khuat Thi Hai
Rapoud, Delphine
Quillet, Catherine
Thi, Tuyết Thanh Nham
Vallo, Roselyne
Hoang, Giang Thi
Moles, Jean-Pierre
Laureillard, Didier
Feelemyer, Jonathan
Des Jarlais, Don C.
Michel, Laurent
Nagot, Nicolas
author_sort Moulis, Lionel
collection PubMed
description BACKGROUND: The co-occurrence of substance use disorder and mental disorder, known as dual diagnosis, has a distressingly high prevalence among individuals grappling with either of these conditions. Mood disorders, especially depression, constitute a substantial burden for People Who Inject Drugs (PWID) and a significant public health concern in Vietnam. Identifying risk factors for depression in PWID is imperative for the development of targeted interventions. METHODS: We enrolled PWID into a cohort using the respondent-driven sampling method. Over a 36-month period, we systematically tracked the emergence of depression and employed multiple imputation in conjunction with a mixed nonlinear model to pinpoint risk factors for depression in this demographic. At inclusion, depression was screened using the PHQ-2 questionnaire, and subsequent episodes of depression were assessed semi-annually using the CES-D8. RESULTS: Three hundred and ninety-one PWID (26.6%) were depressed. Major risk factors for depression included being female, not having a permanent residency, having been hospitalized and using methamphetamine more than weekly. Other risk factors included age, being single, not having a health insurance card and not being on methadone. LIMITATIONS: The exclusion of missing visits and social desirability could have led to selection and information biases. In this observational study, confusion biases are possible despite our best efforts. CONCLUSION: Depression is alarmingly frequent in PWID. In this study taking in account the chronological relationship between sociodemographic and clinical factors and depression, risk factors were identified in this specific setting of low-to-middle income country. The findings highlight the need to develop innovative targeted psychiatric interventions with the help of supporting peers.
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spelling pubmed-106614022023-11-01 Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies Moulis, Lionel Le, Sao Mai Hai, Vinh Vu Huong, Duong Thi Minh, Khuê Pham Oanh, Khuat Thi Hai Rapoud, Delphine Quillet, Catherine Thi, Tuyết Thanh Nham Vallo, Roselyne Hoang, Giang Thi Moles, Jean-Pierre Laureillard, Didier Feelemyer, Jonathan Des Jarlais, Don C. Michel, Laurent Nagot, Nicolas Front Psychiatry Psychiatry BACKGROUND: The co-occurrence of substance use disorder and mental disorder, known as dual diagnosis, has a distressingly high prevalence among individuals grappling with either of these conditions. Mood disorders, especially depression, constitute a substantial burden for People Who Inject Drugs (PWID) and a significant public health concern in Vietnam. Identifying risk factors for depression in PWID is imperative for the development of targeted interventions. METHODS: We enrolled PWID into a cohort using the respondent-driven sampling method. Over a 36-month period, we systematically tracked the emergence of depression and employed multiple imputation in conjunction with a mixed nonlinear model to pinpoint risk factors for depression in this demographic. At inclusion, depression was screened using the PHQ-2 questionnaire, and subsequent episodes of depression were assessed semi-annually using the CES-D8. RESULTS: Three hundred and ninety-one PWID (26.6%) were depressed. Major risk factors for depression included being female, not having a permanent residency, having been hospitalized and using methamphetamine more than weekly. Other risk factors included age, being single, not having a health insurance card and not being on methadone. LIMITATIONS: The exclusion of missing visits and social desirability could have led to selection and information biases. In this observational study, confusion biases are possible despite our best efforts. CONCLUSION: Depression is alarmingly frequent in PWID. In this study taking in account the chronological relationship between sociodemographic and clinical factors and depression, risk factors were identified in this specific setting of low-to-middle income country. The findings highlight the need to develop innovative targeted psychiatric interventions with the help of supporting peers. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10661402/ /pubmed/38025448 http://dx.doi.org/10.3389/fpsyt.2023.1233844 Text en Copyright © 2023 Moulis, Le, Hai, Huong, Minh, Oanh, Rapoud, Quillet, Thi, Vallo, Hoang, Moles, Laureillard, Feelemyer, Des Jarlais, Michel, Nagot and the DRIVE Study Team. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Moulis, Lionel
Le, Sao Mai
Hai, Vinh Vu
Huong, Duong Thi
Minh, Khuê Pham
Oanh, Khuat Thi Hai
Rapoud, Delphine
Quillet, Catherine
Thi, Tuyết Thanh Nham
Vallo, Roselyne
Hoang, Giang Thi
Moles, Jean-Pierre
Laureillard, Didier
Feelemyer, Jonathan
Des Jarlais, Don C.
Michel, Laurent
Nagot, Nicolas
Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies
title Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies
title_full Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies
title_fullStr Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies
title_full_unstemmed Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies
title_short Gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies
title_sort gender, homelessness, hospitalization and methamphetamine use fuel depression among people who inject drugs: implications for innovative prevention and care strategies
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661402/
https://www.ncbi.nlm.nih.gov/pubmed/38025448
http://dx.doi.org/10.3389/fpsyt.2023.1233844
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