Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy

Photo-mediated ultrasound therapy (PUT) is a cavitation-based, highly selective antivascular technique. In this study, the effectiveness and safety of PUT on cutaneous vascular malformation was examined through in vivo experiments in a clinically relevant chicken wattle model, whose microanatomy is...

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Detalles Bibliográficos
Autores principales: Wang, Mingyang, Singh, Rohit, Zhang, Wei, Orringer, Jeffrey S., Paulus, Yannis M., Yang, Xinmai, Wang, Xueding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661455/
https://www.ncbi.nlm.nih.gov/pubmed/38024557
http://dx.doi.org/10.1016/j.xjidi.2023.100237
Descripción
Sumario:Photo-mediated ultrasound therapy (PUT) is a cavitation-based, highly selective antivascular technique. In this study, the effectiveness and safety of PUT on cutaneous vascular malformation was examined through in vivo experiments in a clinically relevant chicken wattle model, whose microanatomy is similar to that of port-wine stain and other hypervascular dermal diseases in humans. Assessed by optical coherence tomography angiography, the blood vessel density in the chicken wattle decreased by 73.23% after one session of PUT treatment in which 0.707 J/cm(2) fluence laser pulses were applied concurrently with ultrasound bursts (n = 7, P

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