Cargando…

Parallel detection of chemical reactions in a microfluidic platform using hyperpolarized nuclear magnetic resonance

The sensitivity of NMR may be enhanced by more than four orders of magnitude via dissolution dynamic nuclear polarization (dDNP), potentially allowing real-time, in situ analysis of chemical reactions. However, there has been no widespread use of the technique for this application and the major limi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeste, Jose, Azagra, Marc, Ortega, Maria A., Portela, Alejandro, Matajsz, Gergő, Herrero-Gómez, Alba, Kim, Yaewon, Sriram, Renuka, Kurhanewicz, John, Vigneron, Daniel B., Marco-Rius, Irene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661666/ https://www.ncbi.nlm.nih.gov/pubmed/37906028 http://dx.doi.org/10.1039/d3lc00474k

Ejemplares similares

Molecular detection of inflammation in cell models using hyperpolarized (13)C-pyruvate
por: Sriram, Renuka, et al.
Publicado: (2018)

Clinically Translatable Hyperpolarized (13)C Bicarbonate pH Imaging Method for Use in Prostate Cancer
por: Mu, Changhua, et al.
Publicado: (2023)

The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized (13)C MRSI
por: Bok, Robert, et al.
Publicado: (2019)

Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized (13)C Pyruvate MRI
por: Sriram, Renuka, et al.
Publicado: (2018)

Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer
por: Korenchan, David E., et al.
Publicado: (2019)

Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized (13)C-Pyruvate MRI
por: Sahin, Sule I., et al.
Publicado: (2023)

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized (13)C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures
por: Sriram, Renuka, et al.
Publicado: (2020)

Clinical translation of hyperpolarized (13)C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging
por: Qin, Hecong, et al.
Publicado: (2021)

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes
por: Qin, Hecong, et al.
Publicado: (2018)

Non-Invasive Differentiation of Benign Renal Tumors from Clear Cell Renal Cell Carcinomas Using Clinically Translatable Hyperpolarized (13)C Pyruvate Magnetic Resonance
por: Sriram, Renuka, et al.
Publicado: (2016)

Polyolefin catalysis of propene, 1-butene and isobutene monitored using hyperpolarized NMR
por: Kim, Yaewon, et al.
Publicado: (2021)

Monitoring response to a clinically relevant IDH inhibitor in glioma—Hyperpolarized (13)C magnetic resonance spectroscopy approaches
por: Hong, Donghyun, et al.
Publicado: (2023)

In Vivo Carbon-13 Dynamic MRS and MRSI of Normal and Fasted Rat Liver with Hyperpolarized (13)C-Pyruvate
por: Hu, Simon, et al.
Publicado: (2009)

Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip
por: Barker, Sylwia J., et al.
Publicado: (2022)

Imaging Renal Urea Handling in Rats at Millimeter Resolution Using Hyperpolarized Magnetic Resonance Relaxometry
por: Reed, Galen D., et al.
Publicado: (2016)

Hyperpolarized (13)C MRI: Path to Clinical Translation in Oncology
por: Kurhanewicz, John, et al.
Publicado: (2018)

High field magnetometry with hyperpolarized nuclear spins
por: Sahin, Ozgur, et al.
Publicado: (2022)

Relayed hyperpolarization for zero-field nuclear magnetic resonance
por: Van Dyke, Erik T., et al.
Publicado: (2022)

A platform for designing hyperpolarized magnetic resonance chemical probes
por: Nonaka, Hiroshi, et al.
Publicado: (2013)

Zero-field nuclear magnetic resonance of chemically exchanging systems
por: Barskiy, Danila A., et al.
Publicado: (2019)

A microfluidic platform for highly parallel bite by bite profiling of mosquito-borne pathogen transmission
por: Kumar, Shailabh, et al.
Publicado: (2021)

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging
por: Li, Yan, et al.
Publicado: (2021)

Hyperpolarized (13)C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study
por: Chen, Hsin-Yu, et al.
Publicado: (2019)

High spatiotemporal resolution hyperpolarized (13)C angiography
por: Reed, Galen D, et al.
Publicado: (2016)

An optimized microfabricated platform for the optical generation and detection of hyperpolarized (129)Xe
por: Kennedy, Daniel J., et al.
Publicado: (2017)

Spin Noise Detection of Nuclear Hyperpolarization at 1.2 K
por: Pöschko, Maria Theresia, et al.
Publicado: (2015)

Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization
por: Baudouin, D., et al.
Publicado: (2016)

Hyperpolarized relaxometry based nuclear T(1) noise spectroscopy in diamond
por: Ajoy, A., et al.
Publicado: (2019)

Assessment of higher-order singular value decomposition denoising methods on dynamic hyperpolarized [1-(13)C]pyruvate MRI data from patients with glioma
por: Vaziri, Sana, et al.
Publicado: (2022)

Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups
por: Elliott, Stuart J., et al.
Publicado: (2018)

Hyperpolarized Xenon Nuclear Magnetic Resonance (NMR) of Building Stone Materials
por: Mauri, Michele, et al.
Publicado: (2012)

Nuclear Overhauser spectroscopy in hyperpolarized water – chemical vs. magnetic exchange
por: Epasto, Ludovica Martina, et al.
Publicado: (2022)

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13)C-labeled cell metabolite and water protons
por: Marco-Rius, Irene, et al.
Publicado: (2014)

Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma
por: Agudelo, Joao Piraquive, et al.
Publicado: (2022)

Multi-parametric hyperpolarized (13)C/(1)H imaging reveals Warburg-related metabolic dysfunction and associated regional heterogeneity in high-grade human gliomas
por: Autry, Adam W., et al.
Publicado: (2023)

Parallel gene synthesis in a microfluidic device
por: Kong, David S., et al.
Publicado: (2007)

Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models
por: Sun, Jinny, et al.
Publicado: (2021)

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse
por: Marco-Rius, Irene, et al.
Publicado: (2013)

Tailored flavoproteins acting as light-driven spin machines pump nuclear hyperpolarization
por: Ding, Yonghong, et al.
Publicado: (2020)

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals
por: Pinon, Arthur C., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rudk4atacrpskjmnj53m988bua