Cargando…

ST2-Conditioned Medium Fosters Dorsal Horn Cell Excitability and Synaptic Transmission in Cultured Mouse Spinal Cord

Conditioned medium obtained from bone marrow-derived stem cells has been proposed as a novel cell-free therapy in spinal cord injury and neuropathic pain, yet the direct effect on spinal neuron function has never been investigated. Here, we adopted spinal cord organotypic cultures (SCOCs) as an expe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Juárez, Esri H., Wood, Chelsea R., Davies, Rebecca, Kehoe, Oksana, Johnson, William E. B., Merighi, Adalberto, Ferrini, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661801/ https://www.ncbi.nlm.nih.gov/pubmed/37674016 http://dx.doi.org/10.1007/s12015-023-10618-x

Ejemplares similares

Mesenchymal stem cell conditioned medium increases glial reactivity and decreases neuronal survival in spinal cord slice cultures
por: Wood, Chelsea R., et al.
Publicado: (2021)

Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization
por: Ferrini, Francesco, et al.
Publicado: (2020)

GABA(B) receptors-mediated tonic inhibition of glutamate release from Aβ fibers in rat laminae III/IV of the spinal cord dorsal horn
por: Salio, Chiara, et al.
Publicado: (2017)

Distinct forms of synaptic inhibition and neuromodulation regulate calretinin-positive neuron excitability in the spinal cord dorsal horn
por: Smith, K.M., et al.
Publicado: (2016)

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn
por: Abraira, Victoria E., et al.
Publicado: (2017)

Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord
por: Leonardon, Benjamin, et al.
Publicado: (2022)

Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes
por: Zhang, Haijun, et al.
Publicado: (2009)

Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn
por: Ohashi, Nobuko, et al.
Publicado: (2015)

Sensory neuron–derived Na(V)1.7 contributes to dorsal horn neuron excitability
por: Alles, Sascha R. A., et al.
Publicado: (2020)

Pain-related synaptic plasticity in spinal dorsal horn neurons: role of CGRP
por: Bird, Gary C, et al.
Publicado: (2006)

Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn
por: Punnakkal, Pradeep, et al.
Publicado: (2014)

Synaptic Targets of Glycinergic Neurons in Laminae I–III of the Spinal Dorsal Horn
por: Miranda, Camila Oliveira, et al.
Publicado: (2023)

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture
por: Hendrich, Janek, et al.
Publicado: (2012)

Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn
por: Heles, Mario, et al.
Publicado: (2021)

Excitability of Rat Superficial Dorsal Horn Neurons Following a Neonatal Immune Challenge
por: Tadros, Melissa A., et al.
Publicado: (2018)

Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn
por: Wrigley, Paul J, et al.
Publicado: (2010)

Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits
por: Polgár, Erika, et al.
Publicado: (2020)

Neuritis and vinblastine-induced axonal transport disruption lead to signs of altered dorsal horn excitability
por: Satkeviciute, Ieva, et al.
Publicado: (2018)

Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559
por: Cheng, Long-Zhen, et al.
Publicado: (2011)

Synaptic Connections of the Neurokinin 1 Receptor-Like Immunoreactive Neurons in the Rat Medullary Dorsal Horn
por: Qi, Jian, et al.
Publicado: (2011)

Mitochondrial superoxide increases excitatory synaptic strength in spinal dorsal horn neurons of neuropathic mice
por: Bae, Chilman, et al.
Publicado: (2018)

Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn
por: Taiji, Ryo, et al.
Publicado: (2021)

Dorsal Horn of Mouse Lumbar Spinal Cord Imaged with CLARITY
por: Sengul, Gulgun, et al.
Publicado: (2020)

Serotonergic Modulation of Nociceptive Circuits in Spinal Cord Dorsal Horn
por: Bardoni, Rita
Publicado: (2019)

The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord
por: Takeda, Daisuke, et al.
Publicado: (2007)

Defining populations of dorsal horn interneurons
por: Graham, Brett A., et al.
Publicado: (2020)

Windup of Nociceptive Flexion Reflex Depends on Synaptic and Intrinsic Properties of Dorsal Horn Neurons in Adult Rats
por: Aby, Franck, et al.
Publicado: (2019)

Neuron Type-Dependent Synaptic Activity in the Spinal Dorsal Horn of Opioid-Induced Hyperalgesia Mouse Model
por: Kearns, Austin, et al.
Publicado: (2021)

Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn
por: Labrakakis, Charalampos, et al.
Publicado: (2009)

Immunofluorescence characterization of spinal cord dorsal horn microglia and astrocytes in horses
por: Meneses, Constanza Stefania, et al.
Publicado: (2017)

Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging
por: Kusudo, Kei, et al.
Publicado: (2006)

Complex regulation of the regulator of synaptic plasticity histone deacetylase 2 in the rodent dorsal horn after peripheral injury
por: Maiarù, Maria, et al.
Publicado: (2016)

Attenuated Glial K(+) Clearance Contributes to Long-Term Synaptic Potentiation Via Depolarizing GABA in Dorsal Horn Neurons of Rat Spinal Cord
por: Lee, Jaekwang, et al.
Publicado: (2014)

Effect of Electroacupuncture at ST36 on Gastric-Related Neurons in Spinal Dorsal Horn and Nucleus Tractus Solitarius
por: Wang, Xiaoyu, et al.
Publicado: (2013)

Interplay of BDNF and GDNF in the Mature Spinal Somatosensory System and Its Potential Therapeutic Relevance
por: Ferrini, Francesco, et al.
Publicado: (2021)

Inward currents induced by ischemia in rat spinal cord dorsal horn neurons
por: Chen, Meng, et al.
Publicado: (2007)

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
por: Kardon, Adam P., et al.
Publicado: (2014)

Differential Modulation of Dorsal Horn Neurons by Various Spinal Cord Stimulation Strategies
por: Lee, Kwan Yeop, et al.
Publicado: (2021)

Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord
por: Quillet, Raphaëlle, et al.
Publicado: (2023)

Mechanisms involved in an increment of multimodal excitability of medullary and upper cervical dorsal horn neurons following cutaneous capsaicin treatment
por: Honda, Kuniya, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_67f17j9nvje5f50dfbnm0abtsh