Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors

In the past decade, induced pluripotent stem cells (iPSCs) technology has significantly progressed in studying malignant solid tumors. This technically feasible reprogramming techniques can reawaken sequestered dormant regions that regulate the fate of differentiated cells. Despite the evolving ther...

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Autores principales: He, Rong, Weng, Zhijie, Liu, Yunkun, Li, Bingzhi, Wang, Wenxuan, Meng, Wanrong, Li, Bo, Li, Longjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661832/
https://www.ncbi.nlm.nih.gov/pubmed/37755647
http://dx.doi.org/10.1007/s12015-023-10633-y
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author He, Rong
Weng, Zhijie
Liu, Yunkun
Li, Bingzhi
Wang, Wenxuan
Meng, Wanrong
Li, Bo
Li, Longjiang
author_facet He, Rong
Weng, Zhijie
Liu, Yunkun
Li, Bingzhi
Wang, Wenxuan
Meng, Wanrong
Li, Bo
Li, Longjiang
author_sort He, Rong
collection PubMed
description In the past decade, induced pluripotent stem cells (iPSCs) technology has significantly progressed in studying malignant solid tumors. This technically feasible reprogramming techniques can reawaken sequestered dormant regions that regulate the fate of differentiated cells. Despite the evolving therapeutic modalities for malignant solid tumors, treatment outcomes have not been satisfactory. Recently, scientists attempted to apply induced pluripotent stem cell technology to cancer research, from modeling to treatment. Induced pluripotent stem cells derived from somatic cells, cancer cell lines, primary tumors, and individuals with an inherited propensity to develop cancer have shown great potential in cancer modeling, cell therapy, immunotherapy, and understanding tumor progression. This review summarizes the evolution of induced pluripotent stem cells technology and its applications in malignant solid tumor. Additionally, we discuss potential obstacles to induced pluripotent stem cell technology. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-106618322023-09-27 Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors He, Rong Weng, Zhijie Liu, Yunkun Li, Bingzhi Wang, Wenxuan Meng, Wanrong Li, Bo Li, Longjiang Stem Cell Rev Rep Article In the past decade, induced pluripotent stem cells (iPSCs) technology has significantly progressed in studying malignant solid tumors. This technically feasible reprogramming techniques can reawaken sequestered dormant regions that regulate the fate of differentiated cells. Despite the evolving therapeutic modalities for malignant solid tumors, treatment outcomes have not been satisfactory. Recently, scientists attempted to apply induced pluripotent stem cell technology to cancer research, from modeling to treatment. Induced pluripotent stem cells derived from somatic cells, cancer cell lines, primary tumors, and individuals with an inherited propensity to develop cancer have shown great potential in cancer modeling, cell therapy, immunotherapy, and understanding tumor progression. This review summarizes the evolution of induced pluripotent stem cells technology and its applications in malignant solid tumor. Additionally, we discuss potential obstacles to induced pluripotent stem cell technology. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2023-09-27 2023 /pmc/articles/PMC10661832/ /pubmed/37755647 http://dx.doi.org/10.1007/s12015-023-10633-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
He, Rong
Weng, Zhijie
Liu, Yunkun
Li, Bingzhi
Wang, Wenxuan
Meng, Wanrong
Li, Bo
Li, Longjiang
Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors
title Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors
title_full Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors
title_fullStr Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors
title_full_unstemmed Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors
title_short Application of Induced Pluripotent Stem Cells in Malignant Solid Tumors
title_sort application of induced pluripotent stem cells in malignant solid tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661832/
https://www.ncbi.nlm.nih.gov/pubmed/37755647
http://dx.doi.org/10.1007/s12015-023-10633-y
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