Using Ribonucleoprotein-based CRISPR/Cas9 to Edit Single Nucleotide on Human Induced Pluripotent Stem Cells to Model Type 3 Long QT Syndrome (SCN5A(±))

Human induced pluripotent stem cells (hiPSCs) have been widely used in cardiac disease modelling, drug discovery, and regenerative medicine as they can be differentiated into patient-specific cardiomyocytes. Long QT syndrome type 3 (LQT3) is one of the more malignant congenital long QT syndrome (LQT...

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Detalles Bibliográficos
Autores principales: Ge, Ning, Liu, Min, Li, Rui, Allen, Nicholas M., Galvin, Joseph, Shen, Sanbing, O’Brien, Timothy, Prendiville, Terence W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661835/
https://www.ncbi.nlm.nih.gov/pubmed/37653182
http://dx.doi.org/10.1007/s12015-023-10602-5

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