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Humanized single-domain antibody targeting HER2 enhances function of chimeric antigen receptor T cells

INTRODUCTION: Chimeric antigen receptors (CARs) can redirect T cells against antigen-expressing tumors, and each component plays an important role in the function and anti-tumor efficacy. It has been reported that using human sequences or a low affinity of CAR single-chain variable fragments (scFvs)...

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Detalles Bibliográficos
Autores principales:	Zheng, Rui, Chen, Yuankun, Zhang, Yiting, Liang, Sixin, Zhao, Xiaojuan, Wang, Yiyi, Wang, Pengju, Meng, Ruotong, Yang, Angang, Yan, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661930/ https://www.ncbi.nlm.nih.gov/pubmed/38022548 http://dx.doi.org/10.3389/fimmu.2023.1258156

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