Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration

Inherent barrier properties of the skin impose significant challenges to the transdermal delivery of drugs to systemic circulation. Here, the ex vivo transdermal permeation and deposition of an anti-malarial prophylactic atovaquone solid drug nanoformulation is radiometrically evaluated following ap...

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Detalles Bibliográficos
Autores principales: Morris, Sam, Long, Mark, Savage, Alison, Owen, Andrew, Rannard, Steve, Cauldbeck, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662085/
https://www.ncbi.nlm.nih.gov/pubmed/38024306
http://dx.doi.org/10.1039/d3na00454f
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author Morris, Sam
Long, Mark
Savage, Alison
Owen, Andrew
Rannard, Steve
Cauldbeck, Helen
author_facet Morris, Sam
Long, Mark
Savage, Alison
Owen, Andrew
Rannard, Steve
Cauldbeck, Helen
author_sort Morris, Sam
collection PubMed
description Inherent barrier properties of the skin impose significant challenges to the transdermal delivery of drugs to systemic circulation. Here, the ex vivo transdermal permeation and deposition of an anti-malarial prophylactic atovaquone solid drug nanoformulation is radiometrically evaluated following application of a solid microneedle format.
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spelling pubmed-106620852023-10-17 Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration Morris, Sam Long, Mark Savage, Alison Owen, Andrew Rannard, Steve Cauldbeck, Helen Nanoscale Adv Chemistry Inherent barrier properties of the skin impose significant challenges to the transdermal delivery of drugs to systemic circulation. Here, the ex vivo transdermal permeation and deposition of an anti-malarial prophylactic atovaquone solid drug nanoformulation is radiometrically evaluated following application of a solid microneedle format. RSC 2023-10-17 /pmc/articles/PMC10662085/ /pubmed/38024306 http://dx.doi.org/10.1039/d3na00454f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Morris, Sam
Long, Mark
Savage, Alison
Owen, Andrew
Rannard, Steve
Cauldbeck, Helen
Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration
title Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration
title_full Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration
title_fullStr Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration
title_full_unstemmed Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration
title_short Ex vivo transdermal delivery of (3)H-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration
title_sort ex vivo transdermal delivery of (3)h-labelled atovaquone solid drug nanoparticles: a comparison of topical, intradermal injection and microneedle assisted administration
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662085/
https://www.ncbi.nlm.nih.gov/pubmed/38024306
http://dx.doi.org/10.1039/d3na00454f
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