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Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation
INTRODUCTION. Limbic encephalitis (LE) can have a wide range of etiologies, most frequently infectious (especially viral) or autoimmune. Behçet’s disease (BD) can present with heterogeneous neurological manifestations. However, LE is not considered a typical presentation of neuro-Behçet’s disease (N...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
EVIDENZE
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662178/ https://www.ncbi.nlm.nih.gov/pubmed/37403244 http://dx.doi.org/10.33588/rn.7702.2022049 |
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author | Seoane, David Roca-Rodríguez, Lucas Ruiz-Ortiz, Mariano Franco-Domingo, Noemí Laespada-García, M. Isabel Sánchez-Tejerina, Daniel González-Crespo, M. Rosa Villarejo-Galende, Alberto González-Sánchez, Marta |
author_facet | Seoane, David Roca-Rodríguez, Lucas Ruiz-Ortiz, Mariano Franco-Domingo, Noemí Laespada-García, M. Isabel Sánchez-Tejerina, Daniel González-Crespo, M. Rosa Villarejo-Galende, Alberto González-Sánchez, Marta |
author_sort | Seoane, David |
collection | PubMed |
description | INTRODUCTION. Limbic encephalitis (LE) can have a wide range of etiologies, most frequently infectious (especially viral) or autoimmune. Behçet’s disease (BD) can present with heterogeneous neurological manifestations. However, LE is not considered a typical presentation of neuro-Behçet’s disease (NBD). CASE REPORT. A 40-years-old male presented with new-onset subacute headaches, memory problems and apathy. A review of systems revealed an unrecorded past history of recurrent oral sores for years, recent malaise and fever, as well as an episode of bilateral panuveitis four months before presentation. His general and neurologic examination revealed slight fever, an isolated oral aphtha, anterograde amnesia and signs of bilateral retinal vasculitis. Brain magnetic resonance imaging displayed a pattern of limbic meningoencephalitis, and his cerebrospinal fluid showed mononuclear inflammation. The patient met BD diagnostic criteria. Considering LE is a very rare presentation of NBD, alternative etiologies were thoroughly assessed and excluded, including infectious, autoimmune and paraneoplastic encephalitis. Therefore, he was diagnosed with NBD, and he recovered well after immunosuppression. DISCUSSION. Only two cases of NBD presenting with LE have been previously reported. We report a third case of this rare presentation and compare it with the previous two. We aim to highlight this association and contribute to enlarge the rich clinical spectrum of NBD. |
format | Online Article Text |
id | pubmed-10662178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | EVIDENZE |
record_format | MEDLINE/PubMed |
spelling | pubmed-106621782023-07-16 Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation Seoane, David Roca-Rodríguez, Lucas Ruiz-Ortiz, Mariano Franco-Domingo, Noemí Laespada-García, M. Isabel Sánchez-Tejerina, Daniel González-Crespo, M. Rosa Villarejo-Galende, Alberto González-Sánchez, Marta Rev Neurol Case Report INTRODUCTION. Limbic encephalitis (LE) can have a wide range of etiologies, most frequently infectious (especially viral) or autoimmune. Behçet’s disease (BD) can present with heterogeneous neurological manifestations. However, LE is not considered a typical presentation of neuro-Behçet’s disease (NBD). CASE REPORT. A 40-years-old male presented with new-onset subacute headaches, memory problems and apathy. A review of systems revealed an unrecorded past history of recurrent oral sores for years, recent malaise and fever, as well as an episode of bilateral panuveitis four months before presentation. His general and neurologic examination revealed slight fever, an isolated oral aphtha, anterograde amnesia and signs of bilateral retinal vasculitis. Brain magnetic resonance imaging displayed a pattern of limbic meningoencephalitis, and his cerebrospinal fluid showed mononuclear inflammation. The patient met BD diagnostic criteria. Considering LE is a very rare presentation of NBD, alternative etiologies were thoroughly assessed and excluded, including infectious, autoimmune and paraneoplastic encephalitis. Therefore, he was diagnosed with NBD, and he recovered well after immunosuppression. DISCUSSION. Only two cases of NBD presenting with LE have been previously reported. We report a third case of this rare presentation and compare it with the previous two. We aim to highlight this association and contribute to enlarge the rich clinical spectrum of NBD. EVIDENZE 2023-07-16 /pmc/articles/PMC10662178/ /pubmed/37403244 http://dx.doi.org/10.33588/rn.7702.2022049 Text en Copyright: © Revista de Neurología https://creativecommons.org/licenses/by-nc-nd/4.0/Revista de Neurología trabaja bajo una licencia Creative Commons |
spellingShingle | Case Report Seoane, David Roca-Rodríguez, Lucas Ruiz-Ortiz, Mariano Franco-Domingo, Noemí Laespada-García, M. Isabel Sánchez-Tejerina, Daniel González-Crespo, M. Rosa Villarejo-Galende, Alberto González-Sánchez, Marta Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation |
title | Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation |
title_full | Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation |
title_fullStr | Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation |
title_full_unstemmed | Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation |
title_short | Limbic encephalitis secondary to neuro-Behçet disease: an uncommon presentation |
title_sort | limbic encephalitis secondary to neuro-behçet disease: an uncommon presentation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662178/ https://www.ncbi.nlm.nih.gov/pubmed/37403244 http://dx.doi.org/10.33588/rn.7702.2022049 |
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