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Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple
INTRODUCTION AND AIMS. Nicolau syndrome, or embolia cutis medicamentosa, is a rare cutaneous complication of drug injection that has been rarely described in relation to medication used in multiple sclerosis. PATIENTS AND METHODS. We conducted a retrospective study of patients with Nicolau syndrome...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
EVIDENZE
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662248/ https://www.ncbi.nlm.nih.gov/pubmed/37466133 http://dx.doi.org/10.33588/rn.7703.2022430 |
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author | Neri, M. José Mulero, Patricia Téllez, Nieves |
author_facet | Neri, M. José Mulero, Patricia Téllez, Nieves |
author_sort | Neri, M. José |
collection | PubMed |
description | INTRODUCTION AND AIMS. Nicolau syndrome, or embolia cutis medicamentosa, is a rare cutaneous complication of drug injection that has been rarely described in relation to medication used in multiple sclerosis. PATIENTS AND METHODS. We conducted a retrospective study of patients with Nicolau syndrome receiving self-injectable multiple sclerosis medication from 2010 to October 2022. RESULTS. From January 2010 to October 2022, 449 patients were followed up in our demyelinating pathology unit with self-injectable drugs - 317 with beta interferons and 132 with glatiramer acetate (GA). In this period of time, 10 episodes of Nicolau syndrome were recorded in seven patients (six men and one woman) receiving GA, which represents 5.3% of the total number of patients receiving this treatment. The most commonly affected areas were the buttocks (n = 4) and the arms (n = 3). Three patients (42.8%) suffered a second episode. CONCLUSION. Nicolau syndrome is a complication unique to GA and more frequent in men in our cohort of multiple sclerosis patients. This cutaneous complication frequently recurs in the same patient, which is a factor to be taken into account in the decision to maintain the drug or switch to another therapeutic strategy. |
format | Online Article Text |
id | pubmed-10662248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | EVIDENZE |
record_format | MEDLINE/PubMed |
spelling | pubmed-106622482023-08-01 Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple Neri, M. José Mulero, Patricia Téllez, Nieves Rev Neurol Original Breve INTRODUCTION AND AIMS. Nicolau syndrome, or embolia cutis medicamentosa, is a rare cutaneous complication of drug injection that has been rarely described in relation to medication used in multiple sclerosis. PATIENTS AND METHODS. We conducted a retrospective study of patients with Nicolau syndrome receiving self-injectable multiple sclerosis medication from 2010 to October 2022. RESULTS. From January 2010 to October 2022, 449 patients were followed up in our demyelinating pathology unit with self-injectable drugs - 317 with beta interferons and 132 with glatiramer acetate (GA). In this period of time, 10 episodes of Nicolau syndrome were recorded in seven patients (six men and one woman) receiving GA, which represents 5.3% of the total number of patients receiving this treatment. The most commonly affected areas were the buttocks (n = 4) and the arms (n = 3). Three patients (42.8%) suffered a second episode. CONCLUSION. Nicolau syndrome is a complication unique to GA and more frequent in men in our cohort of multiple sclerosis patients. This cutaneous complication frequently recurs in the same patient, which is a factor to be taken into account in the decision to maintain the drug or switch to another therapeutic strategy. EVIDENZE 2023-08-01 /pmc/articles/PMC10662248/ /pubmed/37466133 http://dx.doi.org/10.33588/rn.7703.2022430 Text en Copyright: © Revista de Neurología https://creativecommons.org/licenses/by-nc-nd/4.0/Revista de Neurología trabaja bajo una licencia Creative Commons |
spellingShingle | Original Breve Neri, M. José Mulero, Patricia Téllez, Nieves Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple |
title | Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple |
title_full | Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple |
title_fullStr | Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple |
title_full_unstemmed | Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple |
title_short | Síndrome de Nicolau por fármacos autoinyectables en la esclerosis múltiple |
title_sort | síndrome de nicolau por fármacos autoinyectables en la esclerosis múltiple |
topic | Original Breve |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662248/ https://www.ncbi.nlm.nih.gov/pubmed/37466133 http://dx.doi.org/10.33588/rn.7703.2022430 |
work_keys_str_mv | AT nerimjose sindromedenicolauporfarmacosautoinyectablesenlaesclerosismultiple AT muleropatricia sindromedenicolauporfarmacosautoinyectablesenlaesclerosismultiple AT telleznieves sindromedenicolauporfarmacosautoinyectablesenlaesclerosismultiple |