Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion

Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, the transcription factor residing in the PD-L1 super-enhancer has not been comprehensively explored. Through saturated CRISPR-Cas9 screening of the core region of the PD-L1 super-e...

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Detalles Bibliográficos
Autores principales: Shi, Conglin, Chen, Liuting, Pi, Hui, Cui, Henglu, Fan, Chenyang, Tan, Fangzheng, Qu, Xuanhao, Sun, Rong, Zhao, Fengbo, Song, Yihua, Wu, Yuanyuan, Chen, Miaomiao, Ni, Wenkai, Qu, Lishuai, Mao, Renfang, Fan, Yihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662283/
https://www.ncbi.nlm.nih.gov/pubmed/37985752
http://dx.doi.org/10.1038/s41389-023-00500-3

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