Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant

Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into current inhibitors are lacking. Here we present...

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Detalles Bibliográficos
Autores principales: Metcalfe, Riley D., Hanssen, Eric, Fung, Ka Yee, Aizel, Kaheina, Kosasih, Clara C., Zlatic, Courtney O., Doughty, Larissa, Morton, Craig J., Leis, Andrew P., Parker, Michael W., Gooley, Paul R., Putoczki, Tracy L., Griffin, Michael D. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662374/
https://www.ncbi.nlm.nih.gov/pubmed/37985757
http://dx.doi.org/10.1038/s41467-023-42754-w

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