Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants

We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvarian...

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Detalles Bibliográficos
Autores principales: Ong, Chon Phin, Tang, Kaiming, Cheung, Pak-Hin Hinson, Zhang, Hongzhuo, Tang, Tze-Tung, Xue, Yaqian, Wang, Junjue, To, Kelvin Kai-Wang, Yuan, Shuofeng, Ye, Zi-Wei, Jin, Dong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662430/
https://www.ncbi.nlm.nih.gov/pubmed/37985668
http://dx.doi.org/10.1038/s41541-023-00776-x
Descripción
Sumario:We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.

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