Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants

We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvarian...

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Autores principales: Ong, Chon Phin, Tang, Kaiming, Cheung, Pak-Hin Hinson, Zhang, Hongzhuo, Tang, Tze-Tung, Xue, Yaqian, Wang, Junjue, To, Kelvin Kai-Wang, Yuan, Shuofeng, Ye, Zi-Wei, Jin, Dong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662430/
https://www.ncbi.nlm.nih.gov/pubmed/37985668
http://dx.doi.org/10.1038/s41541-023-00776-x
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author Ong, Chon Phin
Tang, Kaiming
Cheung, Pak-Hin Hinson
Zhang, Hongzhuo
Tang, Tze-Tung
Xue, Yaqian
Wang, Junjue
To, Kelvin Kai-Wang
Yuan, Shuofeng
Ye, Zi-Wei
Jin, Dong-Yan
author_facet Ong, Chon Phin
Tang, Kaiming
Cheung, Pak-Hin Hinson
Zhang, Hongzhuo
Tang, Tze-Tung
Xue, Yaqian
Wang, Junjue
To, Kelvin Kai-Wang
Yuan, Shuofeng
Ye, Zi-Wei
Jin, Dong-Yan
author_sort Ong, Chon Phin
collection PubMed
description We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.
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spelling pubmed-106624302023-11-20 Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants Ong, Chon Phin Tang, Kaiming Cheung, Pak-Hin Hinson Zhang, Hongzhuo Tang, Tze-Tung Xue, Yaqian Wang, Junjue To, Kelvin Kai-Wang Yuan, Shuofeng Ye, Zi-Wei Jin, Dong-Yan NPJ Vaccines Brief Communication We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines. Nature Publishing Group UK 2023-11-20 /pmc/articles/PMC10662430/ /pubmed/37985668 http://dx.doi.org/10.1038/s41541-023-00776-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Ong, Chon Phin
Tang, Kaiming
Cheung, Pak-Hin Hinson
Zhang, Hongzhuo
Tang, Tze-Tung
Xue, Yaqian
Wang, Junjue
To, Kelvin Kai-Wang
Yuan, Shuofeng
Ye, Zi-Wei
Jin, Dong-Yan
Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
title Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
title_full Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
title_fullStr Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
title_full_unstemmed Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
title_short Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
title_sort monovalent vaccination with inactivated sars-cov-2 ba.5 protects hamsters against omicron but not non-omicron variants
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662430/
https://www.ncbi.nlm.nih.gov/pubmed/37985668
http://dx.doi.org/10.1038/s41541-023-00776-x
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