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Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs
Small ruminants, especially sheep, are essential for sustainable agricultural production systems, future food/nutrition security, and poverty reduction in developing countries. Within developed countries, the ability of sheep to survive on low-quality forage intake could act as buffer against climat...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662757/ https://www.ncbi.nlm.nih.gov/pubmed/37988399 http://dx.doi.org/10.1371/journal.pone.0291805 |
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author | Cinar, Mehmet Ulas Arslan, Korhan Sohel, Md Mahmodul Hasan Bayram, Davut Piel, Lindsay M. W. White, Stephen N. Daldaban, Fadime Aksel, Esma Gamze Akyüz, Bilal |
author_facet | Cinar, Mehmet Ulas Arslan, Korhan Sohel, Md Mahmodul Hasan Bayram, Davut Piel, Lindsay M. W. White, Stephen N. Daldaban, Fadime Aksel, Esma Gamze Akyüz, Bilal |
author_sort | Cinar, Mehmet Ulas |
collection | PubMed |
description | Small ruminants, especially sheep, are essential for sustainable agricultural production systems, future food/nutrition security, and poverty reduction in developing countries. Within developed countries, the ability of sheep to survive on low-quality forage intake could act as buffer against climate change. Besides sheep’s importance in sustainable agricultural production, there has been less ongoing work in terms of sheep genetics in Near East, Middle East and in Africa. For lamb meat production, body weight and average daily gain (ADG) until weaning are critical economic traits that affects the profitability of the industry. The current study aims to identify single nucleotide polymorphisms (SNPs) that are significantly associated with pre-weaning growth traits in fat tail Akkaraman lambs using a genome-wide association study (GWAS). A total of 196 Akkaraman lambs were selected for analysis. After quality control, a total of 31,936 SNPs and 146 lambs were used for subsequent analyses. PLINK 1.9 beta software was used for the analyses. Based on Bonferroni-adjusted p-values, one SNP (rs427117280) on chromosome 2 (OAR2) had significant associations with weaning weight at day 90 and ADG from day 0 to day 90, which jointly explains a 0.8% and 0.9% of total genetic variation respectively. The Ovis aries natriuretic peptide C (NPPC) could be considered as a candidate gene for the defined significant associations. The results of the current study will help to increase understanding of the variation in weaning weight and ADG until weaning of Akkaraman lambs and help enhance selection for lambs with improved weaning weight and ADG. However, further investigations are required for the identification of causal variants within the identified genomic regions. |
format | Online Article Text |
id | pubmed-10662757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106627572023-11-21 Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs Cinar, Mehmet Ulas Arslan, Korhan Sohel, Md Mahmodul Hasan Bayram, Davut Piel, Lindsay M. W. White, Stephen N. Daldaban, Fadime Aksel, Esma Gamze Akyüz, Bilal PLoS One Research Article Small ruminants, especially sheep, are essential for sustainable agricultural production systems, future food/nutrition security, and poverty reduction in developing countries. Within developed countries, the ability of sheep to survive on low-quality forage intake could act as buffer against climate change. Besides sheep’s importance in sustainable agricultural production, there has been less ongoing work in terms of sheep genetics in Near East, Middle East and in Africa. For lamb meat production, body weight and average daily gain (ADG) until weaning are critical economic traits that affects the profitability of the industry. The current study aims to identify single nucleotide polymorphisms (SNPs) that are significantly associated with pre-weaning growth traits in fat tail Akkaraman lambs using a genome-wide association study (GWAS). A total of 196 Akkaraman lambs were selected for analysis. After quality control, a total of 31,936 SNPs and 146 lambs were used for subsequent analyses. PLINK 1.9 beta software was used for the analyses. Based on Bonferroni-adjusted p-values, one SNP (rs427117280) on chromosome 2 (OAR2) had significant associations with weaning weight at day 90 and ADG from day 0 to day 90, which jointly explains a 0.8% and 0.9% of total genetic variation respectively. The Ovis aries natriuretic peptide C (NPPC) could be considered as a candidate gene for the defined significant associations. The results of the current study will help to increase understanding of the variation in weaning weight and ADG until weaning of Akkaraman lambs and help enhance selection for lambs with improved weaning weight and ADG. However, further investigations are required for the identification of causal variants within the identified genomic regions. Public Library of Science 2023-11-21 /pmc/articles/PMC10662757/ /pubmed/37988399 http://dx.doi.org/10.1371/journal.pone.0291805 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Cinar, Mehmet Ulas Arslan, Korhan Sohel, Md Mahmodul Hasan Bayram, Davut Piel, Lindsay M. W. White, Stephen N. Daldaban, Fadime Aksel, Esma Gamze Akyüz, Bilal Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs |
title | Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs |
title_full | Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs |
title_fullStr | Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs |
title_full_unstemmed | Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs |
title_short | Genome-wide association study of early liveweight traits in fat-tailed Akkaraman lambs |
title_sort | genome-wide association study of early liveweight traits in fat-tailed akkaraman lambs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662757/ https://www.ncbi.nlm.nih.gov/pubmed/37988399 http://dx.doi.org/10.1371/journal.pone.0291805 |
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