A radiation-related second primary gastrointestinal stromal tumor in the bladder

A 69-year-old man underwent 78 Gy/39 Fr of intensity-modulated radiation therapy for prostate cancer. Seven years after radiotherapy, a nonpapillary bladder tumor was identified. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was spindle cell sarcoma. Immu...

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Detalles Bibliográficos
Autores principales: Hori, Mai, Maki, Kazuki, Okuno, Yumiko, Mikami, Koji, Takeuchi, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Special Topic - Advances in Bladder Cancer Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662837/
https://www.ncbi.nlm.nih.gov/pubmed/37994336
http://dx.doi.org/10.1097/CU9.0000000000000186
Descripción
Sumario:A 69-year-old man underwent 78 Gy/39 Fr of intensity-modulated radiation therapy for prostate cancer. Seven years after radiotherapy, a nonpapillary bladder tumor was identified. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was spindle cell sarcoma. Immunostaining revealed KIT(−), DOG1(++), CD34(−), Actin(++), Cytokeratin(−), Desmin(−), S100 protein(−), and Vimentin(++). No tumor recurrence was observed until 17 months after tumor resection. DOG1 is strongly and specifically expressed in gastrointestinal stromal tumors. This was a rare case of bladder gastrointestinal stromal tumor as a radiation-related second primary tumor.

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