A radiation-related second primary gastrointestinal stromal tumor in the bladder

A 69-year-old man underwent 78 Gy/39 Fr of intensity-modulated radiation therapy for prostate cancer. Seven years after radiotherapy, a nonpapillary bladder tumor was identified. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was spindle cell sarcoma. Immu...

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Detalles Bibliográficos
Autores principales: Hori, Mai, Maki, Kazuki, Okuno, Yumiko, Mikami, Koji, Takeuchi, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Special Topic - Advances in Bladder Cancer Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662837/
https://www.ncbi.nlm.nih.gov/pubmed/37994336
http://dx.doi.org/10.1097/CU9.0000000000000186
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author Hori, Mai
Maki, Kazuki
Okuno, Yumiko
Mikami, Koji
Takeuchi, Takumi
author_facet Hori, Mai
Maki, Kazuki
Okuno, Yumiko
Mikami, Koji
Takeuchi, Takumi
author_sort Hori, Mai
collection PubMed
description A 69-year-old man underwent 78 Gy/39 Fr of intensity-modulated radiation therapy for prostate cancer. Seven years after radiotherapy, a nonpapillary bladder tumor was identified. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was spindle cell sarcoma. Immunostaining revealed KIT(−), DOG1(++), CD34(−), Actin(++), Cytokeratin(−), Desmin(−), S100 protein(−), and Vimentin(++). No tumor recurrence was observed until 17 months after tumor resection. DOG1 is strongly and specifically expressed in gastrointestinal stromal tumors. This was a rare case of bladder gastrointestinal stromal tumor as a radiation-related second primary tumor.
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spelling pubmed-106628372023-12-01 A radiation-related second primary gastrointestinal stromal tumor in the bladder Hori, Mai Maki, Kazuki Okuno, Yumiko Mikami, Koji Takeuchi, Takumi Curr Urol Special Topic - Advances in Bladder Cancer Therapy A 69-year-old man underwent 78 Gy/39 Fr of intensity-modulated radiation therapy for prostate cancer. Seven years after radiotherapy, a nonpapillary bladder tumor was identified. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was spindle cell sarcoma. Immunostaining revealed KIT(−), DOG1(++), CD34(−), Actin(++), Cytokeratin(−), Desmin(−), S100 protein(−), and Vimentin(++). No tumor recurrence was observed until 17 months after tumor resection. DOG1 is strongly and specifically expressed in gastrointestinal stromal tumors. This was a rare case of bladder gastrointestinal stromal tumor as a radiation-related second primary tumor. Lippincott Williams & Wilkins 2023-12 2023-03-03 /pmc/articles/PMC10662837/ /pubmed/37994336 http://dx.doi.org/10.1097/CU9.0000000000000186 Text en Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Special Topic - Advances in Bladder Cancer Therapy
Hori, Mai
Maki, Kazuki
Okuno, Yumiko
Mikami, Koji
Takeuchi, Takumi
A radiation-related second primary gastrointestinal stromal tumor in the bladder
title A radiation-related second primary gastrointestinal stromal tumor in the bladder
title_full A radiation-related second primary gastrointestinal stromal tumor in the bladder
title_fullStr A radiation-related second primary gastrointestinal stromal tumor in the bladder
title_full_unstemmed A radiation-related second primary gastrointestinal stromal tumor in the bladder
title_short A radiation-related second primary gastrointestinal stromal tumor in the bladder
title_sort radiation-related second primary gastrointestinal stromal tumor in the bladder
topic Special Topic - Advances in Bladder Cancer Therapy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662837/
https://www.ncbi.nlm.nih.gov/pubmed/37994336
http://dx.doi.org/10.1097/CU9.0000000000000186
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