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Subcortical coding of predictable and unsupervised sound-context associations
Our environment is made of a myriad of stimuli present in combinations often patterned in predictable ways. For example, there is a strong association between where we are and the sounds we hear. Like many environmental patterns, sound-context associations are learned implicitly, in an unsupervised...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663128/ https://www.ncbi.nlm.nih.gov/pubmed/38020811 http://dx.doi.org/10.1016/j.crneur.2023.100110 |
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author | Chen, Chi Cruces-Solís, Hugo Ertman, Alexandra de Hoz, Livia |
author_facet | Chen, Chi Cruces-Solís, Hugo Ertman, Alexandra de Hoz, Livia |
author_sort | Chen, Chi |
collection | PubMed |
description | Our environment is made of a myriad of stimuli present in combinations often patterned in predictable ways. For example, there is a strong association between where we are and the sounds we hear. Like many environmental patterns, sound-context associations are learned implicitly, in an unsupervised manner, and are highly informative and predictive of normality. Yet, we know little about where and how unsupervised sound-context associations are coded in the brain. Here we measured plasticity in the auditory midbrain of mice living over days in an enriched task-less environment in which entering a context triggered sound with different degrees of predictability. Plasticity in the auditory midbrain, a hub of auditory input and multimodal feedback, developed over days and reflected learning of contextual information in a manner that depended on the predictability of the sound-context association and not on reinforcement. Plasticity manifested as an increase in response gain and tuning shift that correlated with a general increase in neuronal frequency discrimination. Thus, the auditory midbrain is sensitive to unsupervised predictable sound-context associations, revealing a subcortical engagement in the detection of contextual sounds. By increasing frequency resolution, this detection might facilitate the processing of behaviorally relevant foreground information described to occur in cortical auditory structures. |
format | Online Article Text |
id | pubmed-10663128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106631282023-10-02 Subcortical coding of predictable and unsupervised sound-context associations Chen, Chi Cruces-Solís, Hugo Ertman, Alexandra de Hoz, Livia Curr Res Neurobiol Articles from the special issue: How Expectation Transforms Neural Representations and Perception, edited by Kerry Walker and Christopher I. Petkov Our environment is made of a myriad of stimuli present in combinations often patterned in predictable ways. For example, there is a strong association between where we are and the sounds we hear. Like many environmental patterns, sound-context associations are learned implicitly, in an unsupervised manner, and are highly informative and predictive of normality. Yet, we know little about where and how unsupervised sound-context associations are coded in the brain. Here we measured plasticity in the auditory midbrain of mice living over days in an enriched task-less environment in which entering a context triggered sound with different degrees of predictability. Plasticity in the auditory midbrain, a hub of auditory input and multimodal feedback, developed over days and reflected learning of contextual information in a manner that depended on the predictability of the sound-context association and not on reinforcement. Plasticity manifested as an increase in response gain and tuning shift that correlated with a general increase in neuronal frequency discrimination. Thus, the auditory midbrain is sensitive to unsupervised predictable sound-context associations, revealing a subcortical engagement in the detection of contextual sounds. By increasing frequency resolution, this detection might facilitate the processing of behaviorally relevant foreground information described to occur in cortical auditory structures. Elsevier 2023-10-02 /pmc/articles/PMC10663128/ /pubmed/38020811 http://dx.doi.org/10.1016/j.crneur.2023.100110 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Articles from the special issue: How Expectation Transforms Neural Representations and Perception, edited by Kerry Walker and Christopher I. Petkov Chen, Chi Cruces-Solís, Hugo Ertman, Alexandra de Hoz, Livia Subcortical coding of predictable and unsupervised sound-context associations |
title | Subcortical coding of predictable and unsupervised sound-context associations |
title_full | Subcortical coding of predictable and unsupervised sound-context associations |
title_fullStr | Subcortical coding of predictable and unsupervised sound-context associations |
title_full_unstemmed | Subcortical coding of predictable and unsupervised sound-context associations |
title_short | Subcortical coding of predictable and unsupervised sound-context associations |
title_sort | subcortical coding of predictable and unsupervised sound-context associations |
topic | Articles from the special issue: How Expectation Transforms Neural Representations and Perception, edited by Kerry Walker and Christopher I. Petkov |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663128/ https://www.ncbi.nlm.nih.gov/pubmed/38020811 http://dx.doi.org/10.1016/j.crneur.2023.100110 |
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