Structural surfaceomics reveals an AML-specific conformation of integrin β(2) as a CAR T cellular therapy target

Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the hypothesis that tumor cells express cancer-specific surface protein conformations that are invisible to standard target discovery pipelines evaluating...

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Detalles Bibliográficos
Autores principales: Mandal, Kamal, Wicaksono, Gianina, Yu, Clinton, Adams, Jarrett J., Hoopmann, Michael R., Temple, William C., Izgutdina, Adila, Escobar, Bonell Patiño, Gorelik, Maryna, Ihling, Christian H., Nix, Matthew A., Naik, Akul, Xie, William H., Hübner, Juwita, Rollins, Lisa A., Reid, Sandy M., Ramos, Emilio, Kasap, Corynn, Steri, Veronica, Serrano, Juan Antonio Camara, Salangsang, Fernando, Phojanakong, Paul, McMillan, Melanie, Gavallos, Victor, Leavitt, Andrew D., Logan, Aaron C., Rooney, Cliona M., Eyquem, Justin, Sinz, Andrea, Huang, Benjamin J., Stieglitz, Elliot, Smith, Catherine C., Moritz, Robert L., Sidhu, Sachdev S., Huang, Lan, Wiita, Arun P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663162/
https://www.ncbi.nlm.nih.gov/pubmed/37904046
http://dx.doi.org/10.1038/s43018-023-00652-6

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