BK channels sustain neuronal Ca(2+) oscillations to support hippocampal long-term potentiation and memory formation

Mutations of large conductance Ca(2+)- and voltage-activated K(+) channels (BK) are associated with cognitive impairment. Here we report that CA1 pyramidal neuron-specific conditional BK knock-out (cKO) mice display normal locomotor and anxiety behavior. They do, however, exhibit impaired memory acq...

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Detalles Bibliográficos
Autores principales: Pham, Thomas, Hussein, Tamara, Calis, Dila, Bischof, Helmut, Skrabak, David, Cruz Santos, Melanie, Maier, Selina, Spähn, David, Kalina, Daniel, Simonsig, Stefanie, Ehinger, Rebekka, Groschup, Bernhard, Knipper, Marlies, Plesnila, Nikolaus, Ruth, Peter, Lukowski, Robert, Matt, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663188/
https://www.ncbi.nlm.nih.gov/pubmed/37989805
http://dx.doi.org/10.1007/s00018-023-05016-y

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