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Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway–mediated disorders

INTRODUCTION: Overactivation of the lectin pathway of complement plays a pathogenic role in a broad range of immune-mediated and inflammatory disorders; mannan-binding lectin-associated serine protease-2 (MASP-2) is the key effector enzyme of the lectin pathway. We developed a fully human monoclonal...

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Detalles Bibliográficos
Autores principales:	Dudler, Thomas, Yaseen, Sadam, Cummings, W. Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663225/ https://www.ncbi.nlm.nih.gov/pubmed/38022610 http://dx.doi.org/10.3389/fimmu.2023.1297352

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