The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies

STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating oppo...

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Autores principales: Wang, Weiyuan, Lopez McDonald, Melanie Cristina, Kim, Christine, Ma, Mirielle, Pan, Zetao (Tommy), Kaufmann, Charlotte, Frank, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663227/
https://www.ncbi.nlm.nih.gov/pubmed/38022653
http://dx.doi.org/10.3389/fimmu.2023.1265818
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author Wang, Weiyuan
Lopez McDonald, Melanie Cristina
Kim, Christine
Ma, Mirielle
Pan, Zetao (Tommy)
Kaufmann, Charlotte
Frank, David A.
author_facet Wang, Weiyuan
Lopez McDonald, Melanie Cristina
Kim, Christine
Ma, Mirielle
Pan, Zetao (Tommy)
Kaufmann, Charlotte
Frank, David A.
author_sort Wang, Weiyuan
collection PubMed
description STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis. In this review, we investigate the specific roles of STAT1 and STAT3 in normal physiology and cancer biology, explore their interactions with each other, and offer insights into therapeutic strategies through modulating their transcriptional activity.
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spelling pubmed-106632272023-01-01 The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies Wang, Weiyuan Lopez McDonald, Melanie Cristina Kim, Christine Ma, Mirielle Pan, Zetao (Tommy) Kaufmann, Charlotte Frank, David A. Front Immunol Immunology STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis. In this review, we investigate the specific roles of STAT1 and STAT3 in normal physiology and cancer biology, explore their interactions with each other, and offer insights into therapeutic strategies through modulating their transcriptional activity. Frontiers Media S.A. 2023-11-08 /pmc/articles/PMC10663227/ /pubmed/38022653 http://dx.doi.org/10.3389/fimmu.2023.1265818 Text en Copyright © 2023 Wang, Lopez McDonald, Kim, Ma, Pan, Kaufmann and Frank https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Weiyuan
Lopez McDonald, Melanie Cristina
Kim, Christine
Ma, Mirielle
Pan, Zetao (Tommy)
Kaufmann, Charlotte
Frank, David A.
The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
title The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
title_full The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
title_fullStr The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
title_full_unstemmed The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
title_short The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
title_sort complementary roles of stat3 and stat1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663227/
https://www.ncbi.nlm.nih.gov/pubmed/38022653
http://dx.doi.org/10.3389/fimmu.2023.1265818
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